SynthesisMedical principles and practice : international journal of the Kuwait University, Health Science Centre2022
Clinical Characteristics and Treatment Outcome of Central Nervous System Nocardiosis: A Systematic Review of Reported Cases.
Synthesis in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The epidemiology, clinical presentation and treatment outcomes in CNS actinomycosis: a systematic review of reported cases.Orphanet journal of rare diseases · 2023Pooled it
- Imaging characteristics, yield of computed tomography, and clinical outcomes of central nervous system nocardiosis.Infection · 2026Article
- A 56-Year-Old Woman With Systemic Lupus Erythematosus on Trimethoprim-Sulfamethoxazole Prophylaxis Presenting With Breakthrough Nocardiosis.The American journal of case reports · 2026Article
- A landscape of epidemiology and strain distribution ofBiosafety and health · 2026Article
- Multi-year population-based study of the clinical and epidemiological risk factors for mortality in nocardiosis: survival analysis from a large regional Canadian healthcare region.BMC infectious diseases · 2026Article
- Multiple IntracranialInfection and drug resistance · 2026Article
- DisseminatedFrontiers in medicine · 2026Article
- Research progress on clinical challenges and prevention strategies of drug-resistantFrontiers in public health · 2026Review
- Article
- Multiple Deep Abscesses Caused by DisseminatedInfection and drug resistance · 2026Article
- Brain Abscess Caused byCurrent HIV research · 2026Article
- PulmonaryCase reports in infectious diseases · 2026Article
- The global epidemiology, risk factors, and mortality prediction of nocardiosis: an easily missed opportunistic infection.Scientific reports · 2025Article
- Nocardia farcinica Brain Abscess in a Glucocorticoid-Treated Patient with Giant-Cell Arteritis: A Case Report.The American journal of case reports · 2025Article
- First reported case of abdominal Nocardia pseudocyst in the setting of a ventriculoperitoneal shunt: a case report and review of literature.Journal of medical case reports · 2025Review
- Article
- Population-based microbiological characterization ofMicrobiology spectrum · 2025Article
- Disseminated Nocardia species infection manifested with multiple brain abscesses and lung involvement in an immunocompetent patient: a case report.Journal of medical case reports · 2025Article
- SLE complicated with Nocardia farcinica bloodstream infection and disseminated nocardiosis: a case report.BMC infectious diseases · 2025Article
- A rare case of multiple brain abscesses caused by Nocardia abscessus co-infection with tuberculous meningitis in an immunocompetent patient.BMC infectious diseases · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical spectrum of systemic nocardiosis encompasses pulmonary and disseminated disease. Central nervous system (CNS) involvement is an important feature of disseminated disease with significant mortality and high relapse rate, especially in those with suppressed cell-mediated immunity. This systematic review aimed to evaluate the epidemiology, clinical features, diagnosis, therapeutic interventions, and outcome in patients with CNS nocardiosis.
methodsA literature search was performed in major databases (PubMed, Google Scholar, and Scopus) by using distinct keywords: "CNS disease," "Nocardia," "meningitis," "brain abscess," "disseminated disease," and "Cotrimoxazole." We included all patients ≥18 years with CNS nocardiosis reported between January 2000 and December 2020.
resultsA total of 129 papers were included in the final analysis. The mean age of patients was 55 ± 16 years, and the majority were male (70.8%). Nocardia farcinica was the commonest species (39.6%), followed by Nocardia nova (5.9%). Thirty-four percent of the patients were found to be immunocompetent. Corticosteroid use was the most common predisposing factor (55.8%). Among neuroimaging findings, brain abscess was most common (86.9%), followed by leptomeningeal enhancement (12.1%). The overall case-fatality rate in CNS disease was 22.8%. On multivariate analysis, patients who underwent surgery (OR 2.4, 95% CI 0.99-4.11, p value 0.046) had better survival than those treated with antimicrobial therapy alone. Immunodeficient state (OR 0.32, 95% CI 0.15-0.90, p value 0.019) was independently associated with poor outcome.
conclusionCNS nocardiosis carries significant mortality, especially in immunodeficient patients. We advocate the use of surgery combined with antimicrobials to improve clinical outcome.
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