Evidence map›Paper›PMID 35700651›Full record

ArticleAquatic toxicology (Amsterdam, Netherlands)2022

Nrf2a dependent and independent effects of early life exposure to 3,3'-dichlorobiphenyl (PCB-11) in zebrafish (Danio rerio).

Monika A Roy, Charlotte K Gridley, Sida Li, Yeonhwa Park, Alicia R Timme-Laragy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aquatic toxicology (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Monika A RoyDepartment of Environmental Health Sciences, University of Massachusetts Amherst, 171B Goessmann Building, 686 N Pleasant St, Amherst, MA 01003, USA; Biotechnology Training Program, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Charlotte K GridleyDepartment of Environmental Health Sciences, University of Massachusetts Amherst, 171B Goessmann Building, 686 N Pleasant St, Amherst, MA 01003, USA.
Sida LiDepartment of Food Science, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Yeonhwa ParkDepartment of Food Science, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Alicia R Timme-LaragyDepartment of Environmental Health Sciences, University of Massachusetts Amherst, 171B Goessmann Building, 686 N Pleasant St, Amherst, MA 01003, USA. Electronic address: aliciat@umass.edu.
University of Massachusetts Amherst · US

Funding

Training CoreP42ES013661 · NIEHS · UNIVERSITY OF IOWA · PI Rachel Frances Marek · 2006 to 2026
$60.3M
Activation of Nrf2 during embryonic development: mechanisms and consequencesR01ES025748 · NIEHS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Alicia R Timme-Laragy · 2016 to 2026
$4.0M
Biotechnology Training Program in Applied Life SciencesT32GM135096 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Jeanne Ann Hardy, Ashish A. Kulkarni · 2020 to 2026
$3.9M
Cellular Engineering Biotechnology Training ProgramT32GM108556 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI HARDY, JEANNE ANN, PEYTON, SHELLY R. · 2015 to 2019
$766k
Investigating the hepatic toxicity of 3,3’-dichlorobiphenyl (PCB-11) in zebrafish (Danio rerio)F31ES030975 · NIEHS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROY, MONIKA · 2019 to 2020
$70k
NIEHS NIH HHS F31 ES030975NIEHS NIH HHS P42 ES013661NIEHS NIH HHS R01 ES025748NIGMS NIH HHS T32 GM108556NIGMS NIH HHS T32 GM135096
6 · The paper itself

Abstract

The environmental pollutant 3,3'-dichlorobiphenyl (PCB-11) is a lower-chlorinated polychlorinated biphenyl (PCB) congener present in air and water samples. Both PCB-11 and its metabolite, 4-PCB-11-Sulfate, are detected in humans, including in pregnant women. Previous research in zebrafish (Danio rerio) has shown that 0.2 μM exposures to 4-PCB-11-Sulfate starting at 1 day post fertilization (dpf) increase hepatic neutral lipid accumulation in larvae at 15 dpf. Here, we explored whether nuclear factor erythroid 2-related factor 2 (Nrf2), known as the master-regulator of the adaptive response to oxidative stress, contributes to metabolic impacts of 4-PCB-11-Sulfate. For this work, embryos were collected from homozygous wildtype or Nrf2a mutant adult zebrafish that also express GFP in pancreatic β-cells, rendering Tg(ins:GFP;nrf2a

Indexed as

Polychlorinated BiphenylsWater Pollutants, ChemicalAdultAnimalsDimethyl SulfoxideEmbryo, NonmammalianFemaleHumansLarvaPregnancySulfatesZebrafish3,3'-dichlorobiphenylDimethyl SulfoxidePolychlorinated BiphenylsSulfatesWater Pollutants, Chemical3,3'-dichloro-4'-sulfooxy-biphenyl3,3'-dichlorobiphenyl4-PCB-11-SulfateDanio rerioFatty acid profilingPancreasPCB-11RNAseqZebrafish

Identifiers

PMID35700651
PMCPMC9701526
OpenAlexW4281789019

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.