Evidence map›Paper›PMID 35700525›Full record

ArticleApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2022

PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice.

Francielly Morena da Silva, Megan E Rosa-Caldwell, Eleanor R Schrems, Lauren Martinez, Madeline G Amos, Seongkyun Lim, Ana Regina Cabrera, Jacob L Brown, Tyrone A Washington, Nicholas P Greene

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Cancer Cachexia.Advances in experimental medicine and biology · 2025
    Review
  6. Article
  7. Review
  8. Exploring heterogeneity: a dive into preclinical models of cancer cachexia.American journal of physiology. Cell physiology · 2024
    Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Francielly Morena da SilvaCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, USA.ORCID 0000-0001-5019-2125
Megan E Rosa-CaldwellCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, USA.
Eleanor R SchremsExercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, USA.
Lauren MartinezCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, USA.
Madeline G AmosCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, USA.
Seongkyun LimCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, USA.
Ana Regina CabreraCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, USA.
Jacob L BrownCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, USA.
Tyrone A WashingtonExercise Muscle Biology Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, USA.
Nicholas P GreeneCachexia Research Laboratory, Exercise Science Research Center, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, USA.
University of Arkansas at Fayetteville · US

Funding

Understanding the Negative Prognostic Impact of Intraosseous Focal Lesions in Multiple MyelomaP20GM125503 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI CHARLES A O'BRIEN · 2018 to 2026
$23.0M
DEVELOPMENT OF TARGETED APPROACHES IN PREVENTION OF CANCER-CACHEXIAR01AR075794 · NIAMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI GREENE, NICHOLAS PERRY · 2020 to 2024
$1.6M
Mitochondrial Degeneration – the Root of Skeletal Muscle AtrophyR15AR069913 · NIAMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI GREENE, NICHOLAS PERRY · 2017 to 2017
$413k
NIAMS NIH HHS R01 AR075794NIAMS NIH HHS R15 AR069913NIGMS NIH HHS P20 GM125503
6 · The paper itself

Abstract

Cancer cachexia (CC) accounts for 20%-40% of cancer-related deaths. Mitochondrial aberrations have been shown to precede muscle atrophy in different atrophy models, including cancer. Therefore, this study investigated potential protection from the cachectic phenotype through overexpression of peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1α). First, to establish potential of mitochondria-based approaches we showed that the mitochondrial antioxidant MitoTEMPO (MitoT) attenuates myotube atrophy induced by Lewis lung carcinoma (LLC) cell conditioned media. Next, cachexia was induced in muscle-specific PGC-1α overexpressing (MCK-PCG1α) or wildtype (WT) littermate mice by LLC implantation. MCK-PCG1α did not protect LLC-induced muscle mass loss. In plantaris,

Indexed as

Carcinoma, Lewis LungMuscular DiseasesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaAnimalsCachexiaFemaleMaleMiceMitochondriaMuscle, SkeletalMuscular AtrophyRNA, MessengerPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseRNA, Messengeratroginatrogineatrophie musculairebiological sexcachexiacachexiecarcinome pulmonaire de LewisLewis lung carcinomamitochondriamitochondriesMitoTEMPOmuscle atrophyPGC-1αsexe biologiqueubiquitine-protéasomeubiquitin–proteasome

Identifiers

PMID35700525
PMCPMC10201462
OpenAlexW4282926857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.