Evidence map›Paper›PMID 35700262›Full record

ReviewEnvironmental science & technology2022

Passive In-Line Chlorination for Drinking Water Disinfection: A Critical Review.

Megan Lindmark, Katya Cherukumilli, Yoshika S Crider, Perrine Marcenac, Matthew Lozier, Lee Voth-Gaeddert, Daniele S Lantagne, James R Mihelcic, Qianjin Marina Zhang, Craig Just and 1 more

2 registry-linked trialsOpen access · hybridAbstract readReview
In one paragraph

Review in Environmental science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
7.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06824350 narecruitingnot on this mapstarted 2025, after this paper: background citation

Multi-component Chlorination Intervention to Reduce Neonatal Infections in Rural Health Facilities

TypeinterventionalSponsorUniversity of California, BerkeleyRan2025 to 2027Enrolled45,450ConditionsSepsis, Neonatal Mortality, Antibiotic Resistant Infection, Enteric InfectionsArmschlorination for water disinfection and surface disinfection, infection prevention and control messaging
NCT07601503 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

In-line Chlorination for Drinking Water Treatment in Nigeria

TypeinterventionalSponsorUniversity of California, BerkeleyRan2026 to 2027Enrolled2,655ConditionsDiarrhea, Water Quality, AdoptionArmsIn-line Chlorination (ILC) with Behavioral Change Communication (BCC)
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 76 citations in OpenAlex.

  1. Trial
  2. Article
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  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Megan LindmarkDepartment of Civil and Environmental Engineering, University of Iowa, Iowa City, Iowa 52242-1396, United States.ORCID 0000-0002-3361-2375
Katya CherukumilliDepartment of Civil and Environmental Engineering, University of California Berkeley, Berkeley, California 94720-2284, United States.ORCID 0000-0002-8606-1845
Yoshika S CriderEnergy & Resources Group, University of California Berkeley, Berkeley, California 94720-2284, United States.
Perrine MarcenacNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, United States.
Matthew LozierNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, United States.
Lee Voth-GaeddertNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, United States.ORCID 0000-0002-9541-1958
Daniele S LantagneTufts University School of Engineering, Medford, Massachusetts 02155-1012, United States.ORCID 0000-0001-6594-0261
James R MihelcicDepartment of Civil and Environmental Engineering, University of South Florida, Tampa, Florida 33620-5350, United States.ORCID 0000-0002-1736-9264
Qianjin Marina ZhangLichtenberger Engineering Library, University of Iowa, Iowa City, Iowa 52242-1396, United States.
Craig JustDepartment of Civil and Environmental Engineering, University of Iowa, Iowa City, Iowa 52242-1396, United States.ORCID 0000-0002-9060-7345
Amy J PickeringDepartment of Civil and Environmental Engineering, University of California Berkeley, Berkeley, California 94720-2284, United States.ORCID 0000-0001-6193-2221
University of Iowa · USCenters for Disease Control and Prevention · USUniversity of California, Berkeley · USCenter for Global Development · USSouth African Medical Research Council · ZATufts University · USUniversity of South Florida · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5M
NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

The world is not on track to meet Sustainable Development Goal 6.1 to provide universal access to safely managed drinking water by 2030. Removal of priority microbial contaminants by disinfection is one aspect of ensuring water is safely managed. Passive chlorination (also called in-line chlorination) represents one approach to disinfecting drinking water before or at the point of collection (POC), without requiring daily user input or electricity. In contrast to manual household chlorination methods typically implemented at the point of use (POU), passive chlorinators can reduce the user burden for chlorine dosing and enable treatment at scales ranging from communities to small municipalities. In this review, we synthesized evidence from 27 evaluations of passive chlorinators (in 19 articles, 3 NGO reports, and 5 theses) conducted across 16 countries in communities, schools, health care facilities, and refugee camps. Of the 27 passive chlorinators we identified, the majority (22/27) were solid tablet or granular chlorine dosers, and the remaining devices were liquid chlorine dosers. We identified the following research priorities to address existing barriers to scaled deployment of passive chlorinators: (i) strengthening local chlorine supply chains through decentralized liquid chlorine production, (ii) validating context-specific business models and financial sustainability, (iii) leveraging remote monitoring and sensing tools to monitor real-time chlorine levels and potential system failures, and (iv) designing handpump-compatible passive chlorinators to serve the many communities reliant on handpumps as a primary drinking water source. We also propose a set of reporting indicators for future studies to facilitate standardized evaluations of the technical performance and financial sustainability of passive chlorinators. In addition, we discuss the limitations of chlorine-based disinfection and recognize the importance of addressing chemical contamination in drinking water supplies. Passive chlorinators deployed and managed at-scale have the potential to elevate the quality of existing accessible and available water services to meet "safely managed" requirements.

Indexed as

Drinking WaterWater PurificationChlorineDisinfectionHalogenationWater SupplyChlorineDrinking Waterchlorine disinfectiondrinking water treatmentlow- and middle-income countriespassive in-line chlorinationresource-constrained settingssafely managed water supply

Identifiers

PMID35700262
PMCPMC9261193
OpenAlexW4282929442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.