ReviewEpilepsia2022
Practical considerations in epilepsy neurostimulation.
Review in Epilepsia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Non-invasive neurostimulation for drug-resistant epilepsy: systematic review and meta-analysis of effectiveness, safety, and optimal stimulation parameters.Journal of neurology · 2025Pooled it
- The comparison of DBS and RNS for adult drug-resistant epilepsy: a systematic review and meta-analysis.Frontiers in human neuroscience · 2024Pooled it
- Network reorganization of anterograde thalamic connectivity during non-periodic patterned deep brain stimulation.iScience · 2026Article
- A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- Corticocortical evoked potential amplitude is altered by cortical stimulation in epilepsy.Epilepsia · 2026Article
- Sequential deep brain stimulation of anterior and centromedian nuclei in juvenile myoclonic epilepsy: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Responsive Neurostimulation in Patients with a History of Viral Brain Infections-A Single-Center Experience.NeuroSci · 2026Article
- Cardiorespiratory cross-frequency coupling biomarker for sudden unexpected death in epilepsy.Epilepsia · 2026Article
- Current best medical practices survey in vagus nerve stimulation programming.Epilepsy & behavior reports · 2026Article
- Neuromodulation in Pediatric Epilepsy: When All Is Not About Resection-A Review.Epilepsy currents · 2026Article
- Safety of Intracranial Neuromodulation in Drug-Resistant Pediatric and Adult Epilepsy.Neurology · 2026Article
- Pathway to Adaptive Neuromodulation: Modeling Epileptogenic Brain States Using SEEG.Epilepsy currents · 2026Article
- Non-invasive neuromodulation for drug-resistant epilepsy: a contemporary structured review of mechanisms, clinical evidence and future directions.Frontiers in neurology · 2026Review
- Clinician, patient, and carer views on neuromodulation for epilepsy: is there rationale for a randomised controlled trial of VNS vs. DBS?Brain & spine · 2026Article
- Thalamocortical seizure onset patterns in drug-resistant focal epilepsy.Brain communications · 2026Article
- Non-invasive neuromodulation for the treatment of drug-resistant epilepsy: Protocol for a systematic review and meta-analysis investigating efficacy, safety, and optimal stimulation parameters.Systematic reviews · 2025Article
- Two-year outcomes of epicranial focal cortex stimulation in pharmacoresistant focal epilepsy.Epilepsia · 2025Article
- The Exchange Breathing Method for Seizure Intervention: A Historical and Scientific Review of Epilepsy and Its Evolving Therapeutic Paradigms.Journal of personalized medicine · 2025Review
- Stereoelectroencephalography for Epilepsy Presurgical Assessment: A Nationwide Survey of Evolution of Practice in Australia.Neurology. Clinical practice · 2025Article
- Intracranial stimulation for pediatric refractory epilepsy: A single institutional experience using evolving therapies.Epilepsia open · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Neuromodulation is a key therapeutic tool for clinicians managing patients with drug-resistant epilepsy. Multiple devices are available with long-term follow-up and real-world experience. The aim of this review is to give a practical summary of available neuromodulation techniques to guide the selection of modalities, focusing on patient selection for devices, common approaches and techniques for initiation of programming, and outpatient management issues. Vagus nerve stimulation (VNS), deep brain stimulation of the anterior nucleus of the thalamus (DBS-ANT), and responsive neurostimulation (RNS) are all supported by randomized controlled trials that show safety and a significant impact on seizure reduction, as well as a suggestion of reduction in the risk of sudden unexplained death in epilepsy (SUDEP). Significant seizure reductions are observed after 3 months for DBS, RNS, and VNS in randomized controlled trials, and efficacy appears to improve with time out to 7 to 10 years of follow-up for all modalities, albeit in uncontrolled follow-up or retrospective studies. A significant number of patients experience seizure-free intervals of 6 months or more with all three modalities. Number and location of epileptogenic foci are important factors affecting efficacy, and together with comorbidities such as severe mood or sleep disorders, may influence the choice of modality. Programming has evolved-DBS is typically initiated at lower current/voltage than used in the pivotal trial, whereas target charge density is lower with RNS, however generalizable optimal parameters are yet to be defined. Noninvasive brain stimulation is an emerging stimulation modality, although it is currently not used widely. In summary, clinical practice has evolved from those established in pivotal trials. Guidance is now available for clinicians who wish to expand their approach, and choice of neuromodulation technique may be tailored to individual patients based on their epilepsy characteristics, risk tolerance, and preferences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.