ArticleAngewandte Chemie (International ed. in English)2022
Enantioselective Synthesis of Enantioisotopomers with Quantitative Chiral Analysis by Chiral Tag Rotational Spectroscopy.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Asymmetric Decarboxylative Protonation and Deuteration of Cyanoacetic Acids Using an Organometallic Proton Shuttle.Journal of the American Chemical Society · 2026Article
- Interstellar Stereoisomerism.ACS earth & space chemistry · 2026Review
- Semi-Reduction of Allenes to Access Deuterated Allylic Isotopomers, Isotopologs and Enantioisotopomers.Angewandte Chemie (International ed. in English) · 2026Article
- Optimizing the Synthesis of Deuterated Isotopomers and Isotopologues of Cyclohexene using Molecular Rotational Resonance Spectroscopy.Journal of the American Chemical Society · 2025Article
- Probing Hydrogen-Bonding Preferences and Methyl Internal Rotation in Sotolon and Sotolon-(HInternational journal of molecular sciences · 2025Article
- Regioselective Cu-Catalyzed Hydrosilylation of Internal Aryl Alkynes.Organic letters · 2025Article
- Tuning Intermolecular Interactions for Chiral Analysis: The Microwave Spectra and Molecular Structures of the Chiral Tag CandidatesThe journal of physical chemistry. A · 2024Article
- C-H amination chemistry mediated by trinuclear Cu(I) sites supported by a ligand scaffold featuring an arene platform and tetramethylguanidinyl residues.Dalton transactions (Cambridge, England : 2003) · 2024Article
- An Automated, Highly Selective Reaction Monitoring Instrument Using Molecular Rotational Resonance Spectroscopy.Precision chemistry · 2024Article
- Article
- Rapid Enantiomeric Excess Measurements of Enantioisotopomers by Molecular Rotational Resonance Spectroscopy.Organic process research & development · 2023Article
- Analysis of isomeric mixtures by molecular rotational resonance spectroscopy.Analytical science advances · 2023Review
- Article
- Deuterodehalogenation Under Net Reductive or Redox-Neutral Conditions Enabled by Paired Electrolysis.Angewandte Chemie (International ed. in English) · 2023Article
- RECENT ADVANCES IN BASE METAL-CATALYZED COOPERATIVE TRANSFER HYDROGENATION AND HYDRODEUTERATION OF ALKENES.Tetrahedron letters · 2023Article
- Highly selective catalytic transfer hydrodeuteration of cyclic alkenes.Journal of labelled compounds & radiopharmaceuticals · 2023Article
- Enantioselective Synthesis of Enantioisotopomers with Quantitative Chiral Analysis by Chiral Tag Rotational Spectroscopy.Angewandte Chemie (International ed. in English) · 2022Article
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8 authors.
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Abstract
Fundamental to the synthesis of enantioenriched chiral molecules is the ability to assign absolute configuration at each stereogenic center, and to determine the enantiomeric excess for each compound. While determination of enantiomeric excess and absolute configuration is often considered routine in many facets of asymmetric synthesis, the same determinations for enantioisotopomers remains a formidable challenge. Here, we report the first highly enantioselective metal-catalyzed synthesis of enantioisotopomers that are chiral by virtue of deuterium substitution along with the first general spectroscopic technique for assignment of the absolute configuration and quantitative determination of the enantiomeric excess of isotopically chiral molecules. Chiral tag rotational spectroscopy uses noncovalent chiral derivatization, which eliminates the possibility of racemization during derivatization, to perform the chiral analysis without the need of reference samples of the enantioisotopomer.
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