Evidence map›Paper›PMID 35699947›Full record

ArticleACS synthetic biology2022

High-Titer Production of the Fungal Anhydrotetracycline, TAN-1612, in Engineered Yeasts.

Pedro A Baldera-Aguayo, Arden Lee, Virginia W Cornish

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. AI-nanotech synergies: recent advances in sustainable bio-manufacturing.World journal of microbiology & biotechnology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Pedro A Baldera-AguayoIntegrated Program in Cellular, Molecular and Biomedical Studies, Columbia University, New York, New York 10032, United States.ORCID 0000-0002-9457-3859
Arden LeeDepartment of Chemistry, Columbia University, 550 W 120th Street, Northwest Corner Building 1206, New York, New York 10027, United States.
Virginia W CornishDepartment of Chemistry, Columbia University, 550 W 120th Street, Northwest Corner Building 1206, New York, New York 10027, United States.
Columbia University · USCancer Research Center · US

Funding

A Household Yeast Biosensor for CholeraR01AI110794 · NIAID · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CORNISH, VIRGINIA W · 2015 to 2019
$3.2M
General and High-Throughput Small Molecule Screens and Selections for Metabolic EngineeringR01GM134293 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CORNISH, VIRGINIA W · 2020 to 2023
$2.5M
NIAID NIH HHS R01 AI110794NIGMS NIH HHS R01 GM134293
6 · The paper itself

Abstract

Antibiotic resistance is a growing global health threat, demanding urgent responses. Tetracyclines, a widely used antibiotic class, are increasingly succumbing to antibiotic resistance; generating novel analogues is therefore a top priority for public health. Fungal tetracyclines provide structural and enzymatic diversity for novel tetracycline analogue production in tractable heterologous hosts, like yeasts, to combat antibiotic-resistant pathogens. Here, we successfully engineered

Indexed as

Saccharomyces cerevisiaeTetracyclinesAnti-Bacterial AgentsYeasts4-epianhydrotetracyclineAnti-Bacterial AgentsTetracyclinesanhydrotetracyclineefflux pumpsSaccharomyces boulardiiSaccharomyces cerevisiaeTAN-1612

Identifiers

PMID35699947
PMCPMC9480237
OpenAlexW4282823166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.