Evidence map›Paper›PMID 35699838›Full record

ArticleAging clinical and experimental research2022

High-intensity interval training modulates inflammatory response in Parkinson's disease.

Paulina Malczynska-Sims, Małgorzata Chalimoniuk, Zbigniew Wronski, Jaroslaw Marusiak, Anna Sulek

Erratum issuedOpen access · hybridAbstract readClinical Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Physical exercise and inflammation in Parkinson's disease: a review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  4. Neurobiology of exercise in Parkinson's disease.Journal of Parkinson's disease · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Paulina Malczynska-SimsDepartment of Genetics, Institute of Psychiatry and Neurology, 9 Sobieskiego St, 02-957, Warsaw, Poland. pmalczynska@ipin.edu.pl.ORCID http://orcid.org/0000-0002-5461-7036
Małgorzata ChalimoniukDepartment of Physical Education and Health in Biała Podlaska, Józef Piłsudski University of Physical Education in Warsaw, 2 Akademicka St, 21-500, Biała Podlaska, Poland.
Zbigniew WronskiDepartment of Rehabilitation, Medical Faculty, Medical University of Warsaw, 61 Żwirki i Wigury St., 02-091, Warsaw, Poland.
Jaroslaw MarusiakDepartment of Kinesiology, University School of Physical Education in Wroclaw, Wroclaw, Poland.
Anna SulekDepartment of Genetics, Institute of Psychiatry and Neurology, 9 Sobieskiego St, 02-957, Warsaw, Poland.
Institute of Psychiatry and Neurology · PLJózef Piłsudski University of Physical Education in Warsaw · PLMedical University of Warsaw · PLWroclaw University of Health and Sport Sciences · PL

Funding

Narodowe Centrum Nauki 2018/31/N/NZ7/02431
6 · The paper itself

Abstract

backgroundRecent discoveries show that high-intensity interval training (HIIT) can bring many positive effects such as decreases in fat tissue, lower blood sugar levels, improved learning and memory, and lower risk of cardiac disease. Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of the dopaminergic neurons, accompanied by chronic inflammation and neuroinflammation. Previous research shows that interval training can bring a beneficial effect on the inflammation and neuroplasticity in PD.

objectivesThe objective of this study was to investigate the effect of 12 weeks of HIIT on the inflammation levels and antioxidant capacity in the serum of PD patients.

methodsTwenty-eight people diagnosed with PD were enrolled in this study. Fifteen PD patients performed 12 weeks of HIIT on a cycloergometer. Thirteen non-exercised PD patients constitute the control group. Concentrations of inflammation markers and antioxidants' capacity in the serum were measured at 3 sampling points (a week before, a week after, and 3 months after the HIIT).

resultsTwelve weeks of HIIT decreases the level of TNF-α (p = 0.034) and increases the level of IL-10 (p = 0.024). Those changes were accompanied by a decreased level of neutrophils (p = 0.03), neutrophil/lymphocyte ratio (p = 0.048) and neutrophil/monocyte ratio (p = 0.0049) with increases in superoxide dismutase levels (p = 0.04).

conclusionsTwelve weeks of HIIT can decrease systemic inflammation in PD patients and improve the antioxidant capacity in their serum, which can slow down the progression of the disease.

Indexed as

High-Intensity Interval TrainingInflammationParkinson DiseaseAntioxidantsFemaleHumansMaleSuperoxide DismutaseAntioxidantsSuperoxide DismutaseAntioxidant capacityHigh-intensity interval trainingHIITInflammationParkinson’s disease

Identifiers

PMID35699838
PMCPMC9192928
OpenAlexW4282841972

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.