Evidence map›Paper›PMID 35699827›Full record

ArticleMolecular and cellular biochemistry2022

A role for the calcium-sensing receptor in the expression of inflammatory mediators in LPS-treated human dental pulp cells.

Shaofeng An, Yanhuo Chen, Ting Yang, Yihua Huang, Yiwei Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Cardioprotective Role of CalhexCell biochemistry and biophysics · 2026
    Review
  3. GPCRs as key regulators in wound healing.Frontiers in cell and developmental biology · 2026
    Review
  4. Low molecular weight hyaluronan inhibits lung epithelial ion channels by activating the calcium-sensing receptor.Matrix biology : journal of the International Society for Matrix Biology · 2023
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shaofeng AnDepartment of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, No. 56 Lingyuan Xi Road, Guangzhou, 510055, Guangdong, People's Republic of China. anshaofeng@outlook.com.ORCID http://orcid.org/0000-0002-5183-9530
Yanhuo ChenDepartment of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, No. 56 Lingyuan Xi Road, Guangzhou, 510055, Guangdong, People's Republic of China.
Ting YangDepartment of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, No. 56 Lingyuan Xi Road, Guangzhou, 510055, Guangdong, People's Republic of China.
Yihua HuangDepartment of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, No. 56 Lingyuan Xi Road, Guangzhou, 510055, Guangdong, People's Republic of China.
Yiwei LiuDepartment of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, No. 56 Lingyuan Xi Road, Guangzhou, 510055, Guangdong, People's Republic of China.
Sun Yat-sen University · CN

Funding

Applied Basic Research Key Project of Yunnan 2019A1515010072National Science Foundation of China 81700957
6 · The paper itself

Abstract

The aim of this study is to investigate the role of calcium-sensing receptor (CaSR) in the expression of inflammatory mediators of lipopolysaccharide (LPS)-treated human dental pulp cells (hDPCs). The expression profile of CaSR in LPS-simulated hDPCs was detected using immunofluorescence, real time quantitative PCR (RT-qPCR), and Western blot analyses. Then, its regulatory effects on the expression of specific inflammatory mediators such as interleukin (IL)-1β, IL-6, cyclooxygenase 2 (COX2)-derived prostaglandin E2 (PGE

Indexed as

Dental PulpInflammation MediatorsReceptors, Calcium-SensingBenzamidesCyclohexylaminesCyclooxygenase 2HumansInterleukin-10Interleukin-6LipopolysaccharidesNF-kappa BProstaglandins EProto-Oncogene Proteins c-aktTumor Necrosis Factor-alphaBenzamidesCyclohexylaminesCyclooxygenase 2Inflammation MediatorsInterleukin-10Interleukin-6LipopolysaccharidesN(1)-(4-chlorobenzoyl)-N(2)-(1-(1-naphthyl)ethyl)-1,2-diaminocyclohexaneNF-kappa BProstaglandins EProto-Oncogene Proteins c-aktReceptors, Calcium-SensingTumor Necrosis Factor-alphaCalcium-sensing receptorDental pulp inflammationHuman dental pulp cellsLipopolysaccharide

Identifiers

PMID35699827
OpenAlexW4282915268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.