ArticleJournal of cancer research and clinical oncology2022
Does first-line immunotherapy impact the efficacy of later treatments: a discussion on the use of second progression-free survival as a research endpoint.
Article in Journal of cancer research and clinical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Immune checkpoint inhibitors or anti-claudin 18.2 antibodies? A network meta-analysis for the optimized first-line therapy of HER2-negative gastric cancer.Therapeutic advances in medical oncology · 2024Article
- Combining immunotherapy with PARP inhibitors. Is it possible to find the way through?Immunotherapy · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, cancer immunotherapy efficacy is measured by endpoints, such as progression-free survival and overall survival, that are unable to reflect authentic responses to checkpoint inhibitors in clinical trials. Second progression-free survival, however, could be an ideal surrogate endpoint due to its easy measurability, correlation with overall survival, and ability to evaluate the efficacy of sequential therapies. This commentary summarizes second progression-free survival data from clinical trials investigating first-line anti-PD-1/PD-L1 therapy in patients with metastatic solid tumors. We speculate that first-line immunotherapies exert a positive influence on the efficacy of later therapies in patients with a few cancer types, though additional research is urgently warranted.
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Registered trials
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