Evidence map›Paper›PMID 35699754›Full record

ArticlePediatric cardiology2023

Reversal of Fetal Heart Block in Antibody-Positive Mother After Hydroxychloroquine and Dexamethasone.

Mehar Hoda, William Scott, Kavita Sharma, Elaine Duryea, Catherine Ikemba

Abstract read
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In one paragraph

Article in Pediatric cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mehar HodaDivision of Pediatric Cardiology, Department of Pediatrics, University of Texas Southwestern Medical Center, 1935 Medical District Dr, Dallas, TX, 75235, USA. mehar.hoda@utsouthwestern.edu.ORCID https://orcid.org/0000-0002-8721-5930
William ScottDivision of Pediatric Cardiology, Department of Pediatrics, University of Texas Southwestern Medical Center, 1935 Medical District Dr, Dallas, TX, 75235, USA.
Kavita SharmaDivision of Pediatric Cardiology, Department of Pediatrics, University of Texas Southwestern Medical Center, 1935 Medical District Dr, Dallas, TX, 75235, USA.
Elaine DuryeaDepartment of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, USA.
Catherine IkembaDivision of Pediatric Cardiology, Department of Pediatrics, University of Texas Southwestern Medical Center, 1935 Medical District Dr, Dallas, TX, 75235, USA.
The University of Texas Southwestern Medical Center · USSouthwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal autoantibody-related complete heart block in the fetus is considered irreversible. During prenatal care for a 25-year-old nulliparous Hispanic woman with newly diagnosed nephrotic-range proteinuria and positive anti-nuclear antigen antibody, complete fetal heart block with a ventricular rate of 60 beats per minute was detected on a fetal echocardiogram at 28-week gestation. A small pericardial effusion and ascites were noted consistent with fetal hydrops. Dexamethasone and hydroxychloroquine were initiated. Fetal rhythm improved to Mobitz type 1 second-degree heart block, with a ventricular rate of 91 beats per minute. The fetus was born prematurely at 34-week gestation with second-degree heart block which improved to first-degree heart block prior to hospital discharge. First-degree heart block persisted at 2 years of age with a P-R interval of 185 ms. Transplacental treatment with dexamethasone and hydroxychloroquine was associated with sustained reversal of complete heart block to sinus rhythm.

Indexed as

Atrioventricular BlockHydroxychloroquineAdultAntibodies, AntinuclearDexamethasoneFemaleFetal HeartHumansMothersPregnancyPrenatal CareAntibodies, AntinuclearDexamethasoneHydroxychloroquineAnti-Ro antibodyAtrioventricular blockHeart blockHydroxychloroquineMaternal lupus

Identifiers

PMID35699754
OpenAlexW4282941219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.