ArticleThe New phytologist2022
Genome-enabled discovery of candidate virulence loci in Striga hermonthica, a devastating parasite of African cereal crops.
Article in The New phytologist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 35 citations in OpenAlex.
- Progress and prospects of parasitic plant biodiversity genomics.Plant & cell physiology · 2026Review
- Genetic Diversity, Predictive Protein Structures, and Interaction Networks of Cysteine-Rich Receptor-Like Kinases inComputational and structural biotechnology journal · 2026Article
- Mechanism of cooperative strigolactone perception by the MAX2 ubiquitin ligase-receptor-substrate complex.Nature communications · 2025Article
- Neofunctionalized RGF pathways drive haustorial organogenesis in parasitic plants.Science advances · 2025Article
- Striga hermonthica induces lignin deposition at the root tip to facilitate prehaustorium formation and obligate parasitism.Plant communications · 2025Article
- Identification of a Papain-like Cysteine Protease Functioning as an Avirulence Factor in Striga-Cowpea Interactions.Plants (Basel, Switzerland) · 2025Article
- Mapping an avirulence gene in the sunflower parasitic weed Orobanche cumana and characterization of host selection based on virulence alleles.BMC plant biology · 2024Article
- Secretory Proteins Are Involved in the Parasitism of Melon byPlants (Basel, Switzerland) · 2024Article
- Evolution of FLOWERING LOCUS T-like genes in angiosperms: a core Lamiales-specific diversification.Journal of experimental botany · 2024Article
- Current status of community resources and priorities for weed genomics research.Genome biology · 2024Review
- A cluster of putative resistance genes is associated with a dominant resistance to sunflower broomrape.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Comparative secretome analysis of Striga and Cuscuta species identifies candidate virulence factors for two evolutionarily independent parasitic plant lineages.BMC plant biology · 2024Article
- Integrated Transcriptome and Proteome Analysis Reveals That Cell Wall Activity AffectsPlants (Basel, Switzerland) · 2024Article
- A roadmap of haustorium morphogenesis in parasitic plants.Journal of experimental botany · 2023Article
- Phenolic signals for prehaustorium formation inFrontiers in plant science · 2022Article
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7 authors at 3 institutions in 3 countries.
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Abstract
Parasites have evolved proteins, virulence factors (VFs), that facilitate plant colonisation, however VFs mediating parasitic plant-host interactions are poorly understood. Striga hermonthica is an obligate, root-parasitic plant of cereal hosts in sub-Saharan Africa, causing devastating yield losses. Understanding the molecular nature and allelic variation of VFs in S. hermonthica is essential for breeding resistance and delaying the evolution of parasite virulence. We assembled the S. hermonthica genome and identified secreted proteins using in silico prediction. Pooled sequencing of parasites growing on a susceptible and a strongly resistant rice host allowed us to scan for loci where selection imposed by the resistant host had elevated the frequency of alleles contributing to successful colonisation. Thirty-eight putatively secreted VFs had very different allele frequencies with functions including host cell wall modification, protease or protease inhibitor and kinase activities. These candidate loci had significantly higher Tajima's D than the genomic background, consistent with balancing selection. Our results reveal diverse strategies used by S. hermonthica to overcome different layers of host resistance. Understanding the maintenance of variation at virulence loci by balancing selection will be critical to managing the evolution of virulence as part of a sustainable control strategy.
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