ArticleRadiology2022
Validation of Artificial Intelligence Cardiac MRI Measurements: Relationship to Heart Catheterization and Mortality Prediction.
Erratum issuedOpen access · hybridAbstract readMulticenter Study
In one paragraph
Article in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- A Comprehensive Review of Artificial Intelligence (AI) Applications in Pulmonary Hypertension (PH).Medicina (Kaunas, Lithuania) · 2025Pooled it
- Artificial Intelligence and Multi-Omics Approaches in the Precision Management of Pulmonary Hypertension: From Early Diagnosis to Therapeutic Stratification.International journal of molecular sciences · 2026Review
- Advancements in Cardiac Magnetic Resonance Imaging: Innovations, Challenges, and Future Directions.Reviews in cardiovascular medicine · 2026Review
- Cardiac magnetic resonance-derived left heart parameters in pulmonary hypertension: diagnostic and prognostic value-a narrative review.Cardiovascular diagnosis and therapy · 2026Review
- ERS Congress 2025: highlights from the Clinical Techniques, Imaging and Endoscopy Assembly.ERJ open research · 2026Article
- Enhancing accuracy of detecting left atrial dilatation on CT pulmonary angiography.European journal of radiology open · 2025Article
- Advances in the imaging of pulmonary hypertension.International journal of cardiology. Congenital heart disease · 2025Review
- Current State of Artificial Intelligence in Assessing Cardiac Function.Current cardiology reports · 2025Review
- Diagnostic value of fully automated CT pulmonary angiography in patients with chronic thromboembolic pulmonary hypertension and chronic thromboembolic disease.European radiology · 2025Article
- Artificial Intelligence in Diagnosis of Heart Failure.Journal of the American Heart Association · 2025Review
- Clinical applications of artificial intelligence and machine learning in neurocardiology: a comprehensive review.Frontiers in cardiovascular medicine · 2025Review
- Artificial intelligence for cardiac imaging is ready for widespread clinical use: Pro Con debate AI for cardiac imaging.BJR open · 2025Review
- Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series).Pulmonary circulation · 2025Article
- Pathology and pathobiology of pulmonary hypertension: current insights and future directions.The European respiratory journal · 2024Review
- Prospective Human Validation of Artificial Intelligence Interventions in Cardiology: A Scoping Review.JACC. Advances · 2024Article
- Development and validation of AI-derived segmentation of four-chamber cine cardiac magnetic resonance.European radiology experimental · 2024Article
- Differential Stroke Volume between Left and Right Ventricles as a Predictor of Clinical Outcomes: The MESA Study.Radiology · 2024Article
- [Research progress on bioinformatics in pulmonary arterial hypertension].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Review
- Clinical assessment of an AI tool for measuring biventricular parameters on cardiac MR.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
24 authors at 3 institutions in 5 countries.
Samer AlabedFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0002-9960-7587
Faisal AlandejaniFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0003-1227-401X
Krit DwivediFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0003-4949-4550
Kavita KarunasaagararFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0003-3151-4760
Michael SharkeyFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0001-9851-0014
Pankaj GargFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0002-5483-169X
Patrick J H de KoningFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0002-5327-270X
Attila TóthFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0002-4081-7168
Yousef ShahinFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0001-7425-7798
Christopher JohnsFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0003-3724-0430
Michail MamalakisFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0002-4276-4119
Sarah StottFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).
David CapenerFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0003-2394-8729
Steven WoodFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0002-5647-1990
Peter MetherallFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).
Alexander M K RothmanFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).
Robin CondliffeFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).
Neil HamiltonFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0002-3731-8165
James M WildFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0002-7246-8660
Declan P O'ReganFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0002-0691-0270
Haiping LuFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0002-0349-2181
David G KielyFrom the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0003-0184-6502
Rob J van der Geest *From the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0002-9084-5597
Andrew J Swift *From the Department of Infection, Immunity, and Cardiovascular Disease (S.A., F.A., K.D., M.A., P.G., Y.S., C.J., S.S., D.C., A.M.K.R., R.C., N.H., J.M.W., D.G.K., A.J.S.), INSIGNEO, Institute for in silico Medicine (S.A., J.M.W., D.G.K., A.J.S.), and Department of Computer Science (M.M., H.L.), University of Sheffield, Glossop Road, Sheffield S10 2JF, UK; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, UK (S.A., K.D., K.K., M.S., Y.S., C.J., S.W., P.M.); Leiden University Medical Center, Leiden, the Netherlands (P.J.H.d.K., R.J.v.d.G.); Semmelweis University Heart and Vascular Center, Budapest, Hungary (A.T.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, UK (R.C., D.G.K.); and MRC London Institute of Medical Sciences, Imperial College London, London, UK (D.P.O.).ORCID 0000-0002-8772-409X
MACOM (United States) · USSemmelweis University · HUMRC London Institute of Medical Sciences · GB
Funding
British Heart Foundation RG/19/6/34387British Heart Foundation SP/14/6/31350Department of Health AI_AWARD01706Medical Research Council MC-A658-5QEBMedical Research Council MC_UP_1605/13Medical Research Council MR/M008894/1Wellcome Trust 205188/Z/16/Z
Abstract
Background Cardiac MRI measurements have diagnostic and prognostic value in the evaluation of cardiopulmonary disease. Artificial intelligence approaches to automate cardiac MRI segmentation are emerging but require clinical testing. Purpose To develop and evaluate a deep learning tool for quantitative evaluation of cardiac MRI functional studies and assess its use for prognosis in patients suspected of having pulmonary hypertension. Materials and Methods A retrospective multicenter and multivendor data set was used to develop a deep learning-based cardiac MRI contouring model using a cohort of patients suspected of having cardiopulmonary disease from multiple pathologic causes. Correlation with same-day right heart catheterization (RHC) and scan-rescan repeatability was assessed in prospectively recruited participants. Prognostic impact was assessed using Cox proportional hazard regression analysis of 3487 patients from the ASPIRE (Assessing the Severity of Pulmonary Hypertension In a Pulmonary Hypertension Referral Centre) registry, including a subset of 920 patients with pulmonary arterial hypertension. The generalizability of the automatic assessment was evaluated in 40 multivendor studies from 32 centers. Results The training data set included 539 patients (mean age, 54 years ± 20 [SD]; 315 women). Automatic cardiac MRI measurements were better correlated with RHC parameters than were manual measurements, including left ventricular stroke volume (
Indexed as
Hypertension, PulmonaryArtificial IntelligenceCardiac CatheterizationFemaleHeart VentriclesHumansMagnetic Resonance ImagingMiddle AgedRetrospective Studies
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