Evidence map›Paper›PMID 35699443›Full record

Trial reportAntimicrobial agents and chemotherapy2022

Efficacy of Cochleated Amphotericin B in Mouse and Human Mucocutaneous Candidiasis.

Jigar V Desai, Amanda Urban, Doris Z Swaim, Benjamin Colton, Lilian W Kibathi, Elise M N Ferrè, Pamela Stratton, Melissa A Merideth, Sally Hunsberger, Theresa Matkovits and 5 more

Open access · greenAbstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Microorganisms · 2024
    Article
  11. Review
  12. Review
  13. Review
  14. Chronic Mucocutaneous Candidiasis: A Case Report.Clinical, cosmetic and investigational dermatology · 2023
    Article
  15. Review
  16. Protothecosis in Dogs: A Narrative Review.Journal of veterinary internal medicine
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Jigar V Desai *Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Amanda Urban *Clinical Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Doris Z SwaimClinical Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Benjamin ColtonPharmacy Department, NIH Clinical Center, NIH, Bethesda, MD, USA.
Lilian W KibathiPharmacy Department, NIH Clinical Center, NIH, Bethesda, MD, USA.
Elise M N FerrèLaboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Pamela StrattonOffice of the Clinical Director, National Institute of Neurological Disease and Stroke, NIH, Bethesda, MD, USA.
Melissa A MeridethNational Human Genome Research Institute, NIH, Bethesda, MD, USA.
Sally HunsbergerBiostatistics Research Branch, Division of Clinical Research (DCR), NIAID NIH, Bethesda, MD, USA.
Theresa MatkovitsMatinas BioPharma Nanotechnologies Inc., Bedminster NJ, USA.
Raphael ManninoMatinas BioPharma Nanotechnologies Inc., Bedminster NJ, USA.
Steven M HollandLaboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Edmund TramontNIAID, NIH, Bethesda, MD, USA.
Michail S Lionakis *Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0003-4994-9500
Alexandra F Freeman *Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
National Institutes of Health · USFrederick National Laboratory for Cancer Research · USNational Institutes of Health Clinical Center · USNational Human Genome Research Institute · USNational Institute of Neurological Disorders and Stroke · US

Funding

Immunopathogenesis of Fungal InfectionsZIAAI001175 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LIONAKIS, MICHAIL · 2012 to 2025
$23.9M
Genes And Gene Products As ImmunoadjuvantsZIAAI000647 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.6M
Transgenic Animal Models Of Human Immune DefectsZIAAI000646 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.2M
Primary Immune Deficiency ClinicZIAAI001247 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FREEMAN, ALEXANDRA · 2019 to 2025
$8.7M
Intramural NIH HHS ZIA AI001175NIAID NIH HHS K99 AI141622
6 · The paper itself

Abstract

Candida albicans causes debilitating, often azole-resistant, infections in patients with chronic mucocutaneous candidiasis (CMC). Amphotericin B (AMB) resistance is rare, but AMB use is limited by parenteral administration and nephrotoxicity. In this study, we evaluated cochleated AMB (CAMB), a new oral AMB formulation, in mouse models of oropharyngeal candidiasis (OPC) and vulvovaginal candidiasis (VVC) and in patients with azole-resistant CMC. OPC and VVC were modeled in

Indexed as

Amphotericin BCandidiasisCandidiasis, Chronic MucocutaneousAnimalsAntifungal AgentsAzolesCandida albicansCandidiasis, OralCandidiasis, VulvovaginalFemaleHumansMiceAmphotericin BAntifungal AgentsAzolesamphotericin Bchronic mucocutaneous candidiasiscochleatedmouse modelmucosal candidiasisphase 2 trial

Identifiers

PMID35699443
PMCPMC9295580
OpenAlexW4282823106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.