Evidence map›Paper›PMID 35699442›Full record

ArticleAntimicrobial agents and chemotherapy2022

Candida parapsilosis Mdr1B and Cdr1B Are Drivers of Mrr1-Mediated Clinical Fluconazole Resistance.

Laura A Doorley, Jeffrey M Rybak, Elizabeth L Berkow, Qing Zhang, Joachim Morschhäuser, P David Rogers

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Relative contributions of the ERG11Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2026
    Article
  6. Catechin Augments the Antifungal Efficacy of Fluconazole AgainstInternational journal of molecular sciences · 2026
    Article
  7. Detection of Fluconazole Resistance inJournal of fungi (Basel, Switzerland) · 2025
    Article
  8. Review
  9. Article
  10. Mutations inAntimicrobial agents and chemotherapy · 2025
    Article
  11. Recent advances in diagnostic technologies for postoperative central nervous system infections: a review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  12. Article
  13. Review
  14. Resistance to Azoles inJournal of fungi (Basel, Switzerland) · 2025
    Article
  15. Emerging fluconazole-resistantFrontiers in microbiology · 2025
    Article
  16. Article
  17. Threats from theMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Laura A DoorleyDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jeffrey M RybakDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Elizabeth L BerkowCollege of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Qing ZhangDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Joachim MorschhäuserInstitute for Molecular Infection Biology, University of Würzburg, Würzburg, Germany.ORCID 0000-0003-4227-8687
P David RogersDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-4401-0679
St. Jude Children's Research Hospital · USUniversity of Tennessee Health Science Center · USUniversity of Würzburg · DE

Funding

Upc2A: A Central Regulator and "Achilles' Heel" of Fluconazole Resistance in Candida glabrataR01AI131620 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI ROGERS, P. DAVID · 2017 to 2021
$2.7M
NIAID NIH HHS R01 AI131620
6 · The paper itself

Abstract

Candida parapsilosis is a common cause of invasive candidiasis worldwide and is the most commonly is7olated

Indexed as

Candida parapsilosisDrug Resistance, FungalFluconazoleAntifungal AgentsATP-Binding Cassette TransportersCandida albicansFungal ProteinsGene Expression Regulation, FungalHumansMembrane Transport ProteinsMicrobial Sensitivity TestsAntifungal AgentsATP-Binding Cassette TransportersFluconazoleFungal ProteinsMembrane Transport ProteinsCandida parapsilosisfluconazoleMRR1resistance

Identifiers

PMID35699442
PMCPMC9295576
OpenAlexW4282827337

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.