Evidence map›Paper›PMID 35699413›Full record

ArticleeLife2022

Functional abnormalities in the cerebello-thalamic pathways in a mouse model of DYT25 dystonia.

Hind Baba Aïssa, Romain W Sala, Elena Laura Georgescu Margarint, Jimena Laura Frontera, Andrés Pablo Varani, Fabien Menardy, Assunta Pelosi, Denis Hervé, Clément Léna, Daniela Popa

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Distinct Brain Drivers and Shared Cerebello-Cortical Input in ADCY5 and SGCE Hyperkinetic Movements.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  2. The Gut Microbiota Regulates Motor Deficits via Butyrate in a GnalAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Abnormal Connectivity of the Head Neural Integrator in Cervical Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2025
    Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025
    Article
  9. Cerebellar deep brain stimulation as a dual-function therapeutic for restoring movement and sleep in dystonic mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Article
  10. Network localization of pediatric lesion-induced dystonia.medRxiv : the preprint server for health sciences · 2024
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hind Baba Aïssa *Neurophysiology of Brain Circuits Team, Institut de biologie de l'Ecole normale supérieure (IBENS), Ecole normale supérieure, CNRS, INSERM, PSL Research University, Paris, France.
Romain W Sala *Neurophysiology of Brain Circuits Team, Institut de biologie de l'Ecole normale supérieure (IBENS), Ecole normale supérieure, CNRS, INSERM, PSL Research University, Paris, France.
Elena Laura Georgescu Margarint *Neurophysiology of Brain Circuits Team, Institut de biologie de l'Ecole normale supérieure (IBENS), Ecole normale supérieure, CNRS, INSERM, PSL Research University, Paris, France.
Jimena Laura FronteraNeurophysiology of Brain Circuits Team, Institut de biologie de l'Ecole normale supérieure (IBENS), Ecole normale supérieure, CNRS, INSERM, PSL Research University, Paris, France.
Andrés Pablo VaraniNeurophysiology of Brain Circuits Team, Institut de biologie de l'Ecole normale supérieure (IBENS), Ecole normale supérieure, CNRS, INSERM, PSL Research University, Paris, France.
Fabien MenardyNeurophysiology of Brain Circuits Team, Institut de biologie de l'Ecole normale supérieure (IBENS), Ecole normale supérieure, CNRS, INSERM, PSL Research University, Paris, France.
Assunta PelosiInserm UMR-S 1270, Paris, France.
Denis HervéInserm UMR-S 1270, Paris, France.ORCID 0000-0003-1376-1522
Clément Léna *Neurophysiology of Brain Circuits Team, Institut de biologie de l'Ecole normale supérieure (IBENS), Ecole normale supérieure, CNRS, INSERM, PSL Research University, Paris, France.ORCID 0000-0002-1431-7717
Daniela Popa *Neurophysiology of Brain Circuits Team, Institut de biologie de l'Ecole normale supérieure (IBENS), Ecole normale supérieure, CNRS, INSERM, PSL Research University, Paris, France.ORCID 0000-0002-8389-1122
Inserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dystonia is often associated with functional alterations in the cerebello-thalamic pathways, which have been proposed to contribute to the disorder by propagating pathological firing patterns to the forebrain. Here, we examined the function of the cerebello-thalamic pathways in a model of DYT25 dystonia. DYT25 (

Indexed as

DystoniaDystonic DisordersAnimalsCerebellumDisease Models, AnimalMiceNeural PathwaysThalamuscerebellumdystoniaelectrophysiologyGnalmotor cortexmouseneurosciencethalamus

Identifiers

PMID35699413
PMCPMC9197392
OpenAlexW4282827920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.