ArticleThyroid : official journal of the American Thyroid Association2023
Thyroid Hormone Metabolism: A Historical Perspective.
Article in Thyroid : official journal of the American Thyroid Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Effects of essential metals (iron, zinc, and copper) on thyroid diseases - a narrative review.Frontiers in medicine · 2026Review
- Thyroid hormones and metabolic flexibility: tissue-specific control of energy homeostasis.Frontiers in physiology · 2026Review
- FT3 Levels and Systemic Inflammation: Evidence From a Population-Based NHANES Analysis.Mediators of inflammation · 2026Article
- From Functional Disorder to a Life-Threatening Emergency: A Rare Adolescent Case of Thyrotoxicosis.Cureus · 2026Article
- Mapping the Evolution of Thyroid Ultrasound Research: A 30-year Bibliometric AnalysisCurrent medical imaging · 2025Review
- Levothyroxine dose prediction post-thyroidectomy for differentiated thyroid carcinoma.Frontiers in endocrinology · 2025Article
- Increased thyroid hormone sensitivity is correlated with visceral obesity in patients with type 2 diabetes.Lipids in health and disease · 2024Article
- Research Advancements in the Interplay between T3 and Macrophages.Current medical science · 2024Review
- Metabolic Messengers: Thyroid Hormones.Nature metabolism · 2024Review
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Authors and funding
2 authors.
Funding
Abstract
In this article, starting with the recognition that iodine is essential for normal thyroid function and is a component of thyroid hormone (TH) molecules, we discuss the many seminal observations and discoveries that have led to identification of various pathways of TH metabolism and their potential roles in TH economy and action. We then recount evidence that TH metabolism participates in maintaining the appropriate content of active hormone in a TH-responsive tissue or cell. Thus, metabolism of the TH is not merely a means by which it is degraded and eliminated from the body, but an essential component of an intricate system by which the thyroid exerts its multiple regulatory effects on almost all organs and tissues. The article ends with a summary of the current concepts and some outstanding questions that are awaiting answers.
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Registered trials
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