Expression of apoptosis-related proteins in the pathogenesis of endometrial clear cell carcinoma.

Adam S Johnson, Oluwole Fadare

Open access · greenAbstract read

In one paragraph

Article in International journal of clinical and experimental pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 89% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Adam S JohnsonDepartment of Pathology, Vanderbilt University Medical Center Nashville, TN, USA.

Oluwole FadareDepartment of Pathology, University of California San Diego San Diego, CA, USA.

University of San Diego · USVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe balance of pro- and anti-apoptotic proteins plays a critical role in the regulation of cell death, and a disruption of this delicate balance may eventuate in carcinogenesis through a net reduction in apoptosis. Numerous chemotherapeutic strategies directly or indirectly target apoptotic pathways. However, a thorough assessment of apoptosis-related proteins has not previously been performed in endometrial clear cell carcinoma (CCC). This study aims to determine the significance of 9 apoptosis-related proteins in the pathogenesis of CCC as compared to non-neoplastic endometrium (NNE), low- and high-grade endometrial endometrioid carcinomas (LG-EEC, HG-EEC), and endometrial serous carcinoma (ESC). MATERIALS AND

methodsExpression of 6 anti-apoptotic proteins (Bcl-2, Bcl-xL, cFLIP

resultsMost notably, CCC showed significantly reduced expression of cFLIP

conclusionOur analysis of the expression and correlation patterns of a panel of apoptosis-related proteins suggests that the downregulation of cFLIP

Indexed as

ApoptosisBaxBcl-2Bcl-xLcaspase-3caspase-8cFLIPLendometrial clear cell carcinomaendometrial endometrioid carcinomaendometrial serous carcinomaMcl-1NF-κB/p65surviving

Identifiers

PMID35698635

PMCPMC9187920

OpenAlexW4285744061

What OpenQuestion holds

Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.