Evidence map›Paper›PMID 35698563›Full record

ArticleInternational journal of nanomedicine2022

One-Step Fabrication of Multifunctional PLGA-HMME-DTX@MnO

Jin Cao, Mingxue Zheng, Zhenyan Sun, Zhiye Li, Xueyong Qi, Song Shen

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jin Cao *School of Pharmacy, Jiangsu University, Zhenjiang, 212013, Jiangsu, People's Republic of China.ORCID 0000-0002-3327-2657
Mingxue Zheng *School of Pharmacy, Jiangsu University, Zhenjiang, 212013, Jiangsu, People's Republic of China.ORCID 0000-0002-7986-0251
Zhenyan SunSchool of Pharmacy, Jiangsu University, Zhenjiang, 212013, Jiangsu, People's Republic of China.
Zhiye LiSchool of Pharmacy, Jiangsu University, Zhenjiang, 212013, Jiangsu, People's Republic of China.
Xueyong QiSchool of Pharmacy, Jiangsu University, Zhenjiang, 212013, Jiangsu, People's Republic of China.
Song ShenSchool of Pharmacy, Jiangsu University, Zhenjiang, 212013, Jiangsu, People's Republic of China.
Jiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sonodynamic therapy (SDT) and its synergistic cancer therapy derivatives, such as combined chemotherapy-SDT (chemo-SDT), are promising approaches for tumor treatment. However, the main drawbacks restricting their applications are hypoxia in tumors and the reducing microenvironment or high glutathione (GSH) levels. Methods: In this study, a hybrid metal MnO Results: When low-power ultrasound is applied, the acquired PHD@MnO Conclusion: This study provides a paradigm that rationally engineered multifunctional metal-hybrid nanoparticles can serve as an effective platform for augmenting the antitumor therapeutic efficiency of chemo-SDT.

Indexed as

Manganese CompoundsNanoparticlesCell Line, TumorDocetaxelGlutathioneHematoporphyrinsHumansHypoxiaOxidesDocetaxelGlutathionehematoporphyrin monomethyl etherHematoporphyrinsManganese CompoundsOxidesflash nanoprecipitationGSH-depletionhypoxiamanganese dioxidePLGA nanoparticlesonodynamic therapy

Identifiers

PMID35698563
PMCPMC9188410
OpenAlexW4281842012

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.