ArticleClinical, cosmetic and investigational dermatology2022
Regular Late Bedtime Significantly Affects the Skin Physiological Characteristics and Skin Bacterial Microbiome.
Article in Clinical, cosmetic and investigational dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and Safety of Topical Application of Plant-Based Products on Skin Aging in Healthy Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of cosmetic dermatology · 2025Pooled it
- Precise assessment of facial skin based on multimodal data fusion of the microbiome.Quantitative biology (Beijing, China) · 2026Article
- Digital Exposure and Skin Health in Children and Adolescents: A State-of-the-Art Review.Cureus · 2026Review
- A Review of the Effects of Lifestyle Factors on Skin Aging.American journal of lifestyle medicine · 2026Review
- Circadian rhythms and microbiota: molecular crosstalk and its implications for health and disease.Biology direct · 2026Review
- Associations of Sleep Quality and Perceived Stress with Skin, Scalp, and Hair Health Among 1,017 Chinese Women: A Cross-Sectional Observational Study.Clinical, cosmetic and investigational dermatology · 2026Article
- The Impact of Sleep Quality on Skin Color.Indian dermatology online journal · 2025Article
- Regulation of dermal circadian pathways by a novel topical formulation.International journal of cosmetic science · 2025Article
- Microbial Dynamics: Assessing Skincare Regimens' Impact on the Facial Skin Microbiome and Skin Health Parameters.Microorganisms · 2024Article
- Review
- Facial Physiological Characteristics and Skin Microbiomes Changes are Associated with Body Mass Index (BMI).Clinical, cosmetic and investigational dermatology · 2024Article
- Gender-Related Characterization of Acne in Chinese: A Multiple-Center Cross-Sectional Survey on 13085 Cases.Clinical, cosmetic and investigational dermatology · 2024Article
- Skin biophysical parameters and serum dermokine levels in airline pilots: a comparative study with office workers.Postepy dermatologii i alergologii · 2023Article
- The menstrual cycle regularity and skin: irregular menstrual cycle affects skin physiological properties and skin bacterial microbiome in urban Chinese women.BMC women's health · 2023Article
- The Characteristics of the Skin Physiological Parameters and Facial Microbiome of "Ideal Skin" in Shanghai Women.Clinical, cosmetic and investigational dermatology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Late bedtime is a common form of unhealthy sleep pattern in adulthood, which influences circadian rhythm, and negatively affects health. However, little is known about the effect of regular late bedtime on skin characteristics, particularly on skin microbiome. Objective: To investigate the changes and effects of the regular late bedtime on skin physiological parameters and facial bacterial microbiome of 219 cases of Chinese women aged 18-38 years living in Shanghai. Methods: Based on the Self-Evaluation Questionnaire, bedtime was categorized as 11:00 PM; thus, the volunteers were divided into early bedtime group (S0) and late bedtime group (S1). The physiological parameters of facial skin were measured by non-invasive instrumental methods, and the skin microbiome was analyzed by 16S rRNA high-throughput sequencing. Results: The skin physiological parameters of the late bedtime group exhibited significant decrease in skin hydration content, skin firmness (F4) and elasticity (R2), while TEWL, sebum and wrinkle significantly increased. The result indicated that late bedtime significantly impaired the integrity of skin barrier, damaged skin structure, and disrupted water-oil balance. Furthermore, the analysis of α-diversity, Sobs, Ace and Chao index were found to significantly decrease ( Conclusion: Bedtime is an important factor in maintaining skin health. Regular late bedtime not only damages the skin barrier and skin structure but also reduces the diversity and composition of facial bacterial microbiome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.