Evidence map›Paper›PMID 35698236›Full record

ReviewItalian journal of pediatrics2022

Chilblain-like lesions onset during SARS-CoV-2 infection in a COVID-19-vaccinated adolescent: case report and review of literature.

Roberto Paparella, Luigi Tarani, Enrico Properzi, Francesco Costantino, Chiara Saburri, Roberta Lucibello, Antonio Richetta, Alberto Spalice, Lucia Leonardi

Open access · goldAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Italian journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Year 2022: exploring COVID-19 pandemic in children.Italian journal of pediatrics · 2023
    Review
  2. Review
  3. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature.Clinical, cosmetic and investigational dermatology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Roberto PaparellaDepartment of Maternal and Child Health and Urology, Sapienza University of Rome, Rome, Italy. roberto.paparella@uniroma1.it.ORCID http://orcid.org/0000-0001-7020-1471
Luigi TaraniDepartment of Maternal and Child Health and Urology, Sapienza University of Rome, Rome, Italy.
Enrico ProperziDepartment of Maternal and Child Health and Urology, Sapienza University of Rome, Rome, Italy.
Francesco CostantinoDepartment of Maternal and Child Health and Urology, Sapienza University of Rome, Rome, Italy.
Chiara SaburriDepartment of Maternal and Child Health and Urology, Sapienza University of Rome, Rome, Italy.
Roberta LucibelloDepartment of Maternal and Child Health and Urology, Sapienza University of Rome, Rome, Italy.
Antonio RichettaUnit of Dermatology, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.
Alberto SpaliceDepartment of Maternal and Child Health and Urology, Sapienza University of Rome, Rome, Italy.
Lucia LeonardiDepartment of Maternal and Child Health and Urology, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCOVID toes or chilblain-like skin lesions have been widely reported during COVID-19 pandemic. Most cases were described in patients with negative microbiological tests for SARS-CoV-2, therefore the possible relationship with SARS-CoV-2 infection, as well as with the nowadays broadly available mRNA-based vaccination, has not been fully elucidated.  CASE PRESENTATION: We here describe the case of a 14-year-old male who developed chilblain-like skin eruptions during SARS-CoV-2 infection despite two mRNA-based vaccine doses and review the clinical and epidemiological characteristics of chilblain-like lesions as a cutaneous presentation of COVID-19 in children.

conclusionsMost children and adolescent with COVID toes have a mild or asymptomatic SARS-CoV-2 infection. Our report aims to highlight the possible onset of these skin lesions in vaccinated children, if infection has occurred, and the potential use of systemic corticosteroids as a first line treatment. Additional evidence is required to better understand SARS-CoV-2 infection and cutaneous manifestations in children and determine the relationship between chilblain-like lesions and COVID-19 vaccination.

Indexed as

ChilblainsCOVID-19Skin DiseasesAdolescentChildCOVID-19 VaccinesHumansMalePandemicsRNA, MessengerSARS-CoV-2COVID-19 VaccinesRNA, MessengerCase reportChilblain-like lesionsChildrenCOVID-19SARS-CoV-2 vaccination

Identifiers

PMID35698236
PMCPMC9190458
OpenAlexW4282591250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.