ArticleBMC veterinary research2022
Broiler responses to copper levels and sources: growth, tissue mineral content, antioxidant status and mRNA expression of genes involved in lipid and protein metabolism.
Article in BMC veterinary research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- The Effect of Multi-Strain Probiotics, Zinc and Copper on the Performance of Broiler Chickens Challenged With Clostridium perfringens.Veterinary medicine and science · 2026Article
- Chicken Liver from Broilers Fed Wheat Germ Expeller: A Source of Minerals and Energy in the Human Diet.Foods (Basel, Switzerland) · 2025Article
- The Effect of Chelated Trace Mineral Supplementation in the Form of Proteinates on Broiler Performance Parameters and Mineral Excretion: A Meta-Analysis.Animals : an open access journal from MDPI · 2025Article
- Effects of dietary supplementation of organic and inorganic zinc on the performance characteristics, tissue mineralization, apparent mineral retention, and antioxidant status of broiler chicks.BMC veterinary research · 2025Article
- Physiological and Histological Responses of Awassi Lambs to High Dietary Organic Copper Supplementation.Animals : an open access journal from MDPI · 2025Article
- Cupric citrate supplementation improves growth performance, nutrient utilization, antioxidant capacity, and intestinal microbiota of broilers.Animal bioscience · 2025Article
- Advanced chelate technology-based trace minerals reduce inflammation and oxidative stress in Eimeria-infected broilers by modulating NF-kB and Nrf2 pathways.Scientific reports · 2024Article
- Dietary copper requirement of broilers fed a corn-soybean meal diet during 22-42 d of age.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Effects of dietary minerals deficiency and supplementation on different parts of muscle minerals content in grazing Mongolian sheep.Frontiers in veterinary science · 2024Article
- Effects of Various Copper Sources and Concentrations on Performance, Skeletal Growth, and Mineral Content of Excreta in Broiler Chickens.Biological trace element research · 2023Article
- Effect of Copper Exposure on the Cholesterol Metabolism in Broiler Liver.Biological trace element research · 2023Article
- Unraveling the Role of Metals and Organic Acids in Bacterial Antimicrobial Resistance in the Food Chain.Antibiotics (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFive hundred 8-d old male broilers Cobb500 were randomly allotted into 10 treatments in factorial arrangement with 5 Cu levels (0, 4, 8, 12, and 16 mg/kg), and 2 sources (Cu proteinate, CuPro and Cu sulphate, CuSO4.5H2O) for a 10-d-experiment.
resultsFeed conversion ratio (FCR) was better (P < 0.05) in CuPro fed chicks compared with CuSO4.5H2O group. Average daily feed intake (ADFI) decreased linearly (P < 0.05) as dietary Cu increased. A quadratic response (P < 0.05) to Cu levels was found for FCR, being optimized at 9.87 and 8.84 mg Cu/kg in CuPro and CuSO4.5H2O diets, respectively. Copper supplementation linearly increased liver Cu content (P < 0.05) and tended to linearly increase (P = 0.07) phosphorus (P) and copper in tibia. Manganese and zinc were higher (P < 0.05) in tibia of CuPro fed birds. Broilers fed CuPro exhibited lower liver iron (P < 0.05) content, lower activities of Cu, Zn superoxide dismutase (CuZnSOD) in breast muscle and liver, and glutathione peroxidase in liver. Glutathione peroxidase reduced linearly (P < 0.05) with CuPro levels and increased linearly (P < 0.05) with CuSO4.5H2O levels and were lower (P < 0.05) in all CuPro levels in breast muscle. Breast muscle malondialdehyde concentration tended to be higher (P = 0.08) in broilers fed CuSO4.5H2O. Copper levels linearly increased (P < 0.05) metallothionein (MT) and malate dehydrogenase (MDH) expression in liver, and six-transmembrane epithelial antigen of the prostate-1 (STEAP-1) in the intestine. Copper elicited a quadratic response (P < 0.050) in AKT-1 and mammalian target of rapamycin (mTOR) in breast muscle, CuZnSOD in liver and antioxidant 1 copper chaperone (ATOX 1) in intestine. Broilers fed CuPro exhibited higher mRNA expression of mTOR in muscle breast and lower CuZnSOD in liver and ATOX 1 in intestine. Interaction (P < 0.05) between levels and sources was found in mRNA expression for GSK-3β, MT, and CuZnSOD in breast muscle, FAS and LPL in liver and MT and CTR1 in intestine.
conclusionsCuPro showed beneficial effects on feed conversion and bone mineralization. Organic and inorganic Cu requirements are 9.87 and 8.84 mg Cu/kg, respectively.
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