ArticleBMC pulmonary medicine2022
Prediction of high-flow nasal cannula outcomes at the early phase using the modified respiratory rate oxygenation index.
Article in BMC pulmonary medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Prediction of high-flow nasal cannula failure in critically ill patients: a narrative review.Journal of intensive care · 2026Review
- Real-time prediction of HFNC treatment failure in acute hypoxemic respiratory failure using machine learning.Scientific reports · 2025Article
- Comparisons of mortality predictions of mROX, CURB-65, and APACHE II in patients with severe pneumonia: A retrospective cohort study.Medicine · 2025Article
- Comparison of ROX index with modified indices incorporating heart rate, flow rate, and PaOEuropean journal of medical research · 2025Article
- Machine learning models compared with current clinical indices to predict the outcome of high flow nasal cannula therapy in acute hypoxemic respiratory failure.Critical care (London, England) · 2025Article
- Observational
- Comparison of Modified ROX Index Score and ROX Index Score for Early Prediction of High Flow Nasal Oxygen Therapy Outcome in Patients with Acute Respiratory Failure: A Prospective Observational Cohort Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- ROX index as a predictor of failure of high-flow nasal cannula in infants with bronchiolitis.Scientific reports · 2024Article
- Risk factors analysis and prediction model construction for severe pneumonia in older adult patients.Frontiers in public health · 2024Article
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThis study was designed to explore the early predictive value of the respiratory rate oxygenation (ROX) index modified by PaO
methodSeventy-five patients with AHRF treated with HFNC were retrospectively reviewed. Respiratory parameters at baseline and 2 h after HFNC initiation were analyzed. The predictive value of the ROX (ratio of pulse oximetry/FIO
resultsHFNC therapy failed in 24 patients, who had significantly higher intensive care unit (ICU) mortality and longer ICU stay. Both the ROX and mROX indices at 2 h after HFNC initiation can predict the risk of intubation after HFNC. Two hours after HFNC initiation, the mROX index had a higher area under the receiver operating characteristic curve (AUROC) for predicting HFNC success than the ROX index. Besides, baseline mROX index of greater than 7.1 showed a specificity of 100% for HFNC success.
conclusionThe mROX index may be a suitable predictor of HFNC therapy outcomes at the early phase in patients with AHRF.
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Registered trials
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