Evidence map›Paper›PMID 35698024›Full record

ArticleBrain pathology (Zurich, Switzerland)2023

Targeting the interaction of GABA

Karthik Balakrishnan, Mohammad Hleihil, Musadiq A Bhat, Robert P Ganley, Markus Vaas, Jan Klohs, Hanns Ulrich Zeilhofer, Dietmar Benke

Open access · goldAbstract read
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Restoring GABAFrontiers in molecular neuroscience · 2024
    Article
  7. Restoration of GABANeural regeneration research · 2023
    Article
  8. ERK1/2-Dependent Phosphorylation of GABAInternational journal of molecular sciences · 2023
    Article
  9. Review
  10. Targeting the interaction of GABABrain pathology (Zurich, Switzerland) · 2023
    Article
  11. Review
  12. Protein phosphatase 2A regulation of GABAFrontiers in molecular neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Karthik BalakrishnanInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Mohammad HleihilInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Musadiq A BhatInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-0894-9996
Robert P GanleyInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Markus VaasInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Jan KlohsNeuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
Hanns Ulrich ZeilhoferInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Dietmar BenkeInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-1846-4711
University of Zurich · CH

Funding

Foundation for Research in Science and the Humanities at the University of Zurich STWF-18-005Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31003A_156648Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31003A_182325
6 · The paper itself

Abstract

Cerebral ischemia is the leading cause for long-term disability and mortality in adults due to massive neuronal death. Currently, there is no pharmacological treatment available to limit progressive neuronal death after stroke. A major mechanism causing ischemia-induced neuronal death is the excessive release of glutamate and the associated overexcitation of neurons (excitotoxicity). Normally, GABA

Indexed as

Brain IschemiaReceptors, GABA-BAnimalsBrainCalcium-Calmodulin-Dependent Protein Kinase Type 2Cerebral Infarctiongamma-Aminobutyric AcidMicePeptidesCalcium-Calmodulin-Dependent Protein Kinase Type 2gamma-Aminobutyric AcidPeptidesReceptors, GABA-BCaMKIIcerebral ischemiaGABAB receptorinterfering peptideneuroprotection

Identifiers

PMID35698024
PMCPMC9836377
OpenAlexW4282822479

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.