Evidence map›Paper›PMID 35697979›Full record

ArticleJournal of cardiovascular translational research2023

Matrix Metalloproteinase-Targeted SPECT/CT Imaging for Evaluation of Therapeutic Hydrogels for the Early Modulation of Post-Infarct Myocardial Remodeling.

Stephanie L Thorn, James A Shuman, Mitchel R Stacy, Brendan P Purcell, Heather Doviak, Jason A Burdick, Francis G Spinale, Albert J Sinusas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Stephanie L ThornSection of Cardiovascular Medicine, Department of Medicine, School of Medicine, Yale University, DANA-3, PO Box 208017, New Haven, CT, 06520, USA.ORCID 0000-0003-0020-0814
James A ShumanCardiovascular Translational Research Center, University of South Carolina School of Medicine and the WJB Dorn Veteran Affairs Medical Center, Columbia, SC, USA.
Mitchel R StacyDepartment of Surgery, Ohio State University College of Medicine, Columbus, OH, USA.
Brendan P PurcellDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Heather DoviakCardiovascular Translational Research Center, University of South Carolina School of Medicine and the WJB Dorn Veteran Affairs Medical Center, Columbia, SC, USA.
Jason A BurdickDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Francis G SpinaleCardiovascular Translational Research Center, University of South Carolina School of Medicine and the WJB Dorn Veteran Affairs Medical Center, Columbia, SC, USA.
Albert J SinusasSection of Cardiovascular Medicine, Department of Medicine, School of Medicine, Yale University, DANA-3, PO Box 208017, New Haven, CT, 06520, USA. albert.sinusas@yale.edu.
University of South Carolina · USDana (United States) · USUniversity of Pennsylvania · USThe Ohio State University · US

Funding

Training In Multi-modality Molecular & Translational Cardiovascular ImagingT32HL098069 · NHLBI · YALE UNIVERSITY · PI JAMES S DUNCAN, Georges El Fakhri · 2010 to 2026
$5.2M
Image Guided Delivery of Bioresponsive HydrogelsR01HL137365 · NHLBI · YALE UNIVERSITY · PI BURDICK, JASON A, DUNCAN, JAMES S · 2018 to 2021
$3.2M
Molecular Imaging Predicts Atrial Remodeling and Fibrillation VulnerabilityR01HL113352 · NHLBI · YALE UNIVERSITY · PI AKAR, JOSEPH GABRIEL, SINUSAS, ALBERT J · 2013 to 2016
$2.8M
Fibroblast targeting for myocardial repairR01HL167994 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRANCIS G SPINALE · 2023 to 2026
$2.6M
Proteolytic Imaging of Remodeling MyocardiumR42HL131280 · NHLBI · MICRO VIDE, LLC · PI SPINALE, FRANCIS G · 2016 to 2018
$1.8M
Hybrid Volumetric SPECT/CT Imaging SystemS10RR025555 · NCRR · YALE UNIVERSITY · PI SINUSAS, ALBERT J · 2009 to 2009
$500k
Maladaptive Remodeling in Aging MyocardiumI01BX000168 · VA · VETERANS HEALTH ADMINISTRATION · PI SPINALE, FRANCIS G · 2009 to 2024
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BLRD VA I01 BX000168NCRR NIH HHS S10 RR025555NHLBI NIH HHS R01 HL113352NHLBI NIH HHS R01 HL137365NHLBI NIH HHS R01 HL167994NHLBI NIH HHS R42 HL131280NHLBI NIH HHS T32 HL098069
6 · The paper itself

Abstract

Following myocardial infarction (MI), maladaptive upregulation of matrix metalloproteinase (MMP) alters extracellular matrix leading to cardiac remodeling. Intramyocardial hydrogel delivery provides a vehicle for local delivery of MMP tissue inhibitors (rTIMP-3) for MMP activity modulation. We evaluated swine 10-14 days following MI randomized to intramyocardial delivery of saline, degradable hyaluronic acid (HA) hydrogel, or rTIMP-3 releasing hydrogel with an MMP-targeted radiotracer (

Indexed as

HydrogelsMyocardial InfarctionAnimalsMatrix MetalloproteinasesMyocardiumSwineTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedVentricular RemodelingHydrogelsMatrix MetalloproteinasesCardiac remodelingHydrogelsMatrix metalloproteinaseMyocardial infarctionTIMP-3

Identifiers

PMID35697979
PMCPMC10836411
OpenAlexW4282561599

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.