ArticleBiomechanics and modeling in mechanobiology2022
Fluid-structure interaction (FSI) simulation for studying the impact of atherosclerosis on hemodynamics, arterial tissue remodeling, and initiation risk of intracranial aneurysms.
Article in Biomechanics and modeling in mechanobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- An open-source computational framework for immersed fluid-structure interaction modeling using FEBio and MFEM.Engineering with computers · 2026Article
- Biomechanical stress profiling in coronary arteries via two-phase blood FSI.Biomechanics and modeling in mechanobiology · 2025Article
- An in silico analysis of heart rate impact on wall shear stress hemodynamic parameters in aortic coarctation.Scientific reports · 2025Article
- Linc-ROR Modulates the Endothelial-Mesenchymal Transition of Endothelial Progenitor Cells through the miR-145/Smad3 Signaling Pathway.Physiological research · 2024Article
- Multi-scaled temporal modeling of cardiovascular disease progression: An illustration of proximal arteries in pulmonary hypertension.Journal of biomechanics · 2024Article
- A mechanical modeling framework to study endothelial permeability.Biophysical journal · 2024Article
- Quantification of morpho-hemodynamic changes in unruptured intracranial aneurysms with irregular pulsation during the cardiac cycle using 4D-CTA.Frontiers in neurology · 2024Article
- Computational Fluid Dynamic Simulations of Cerebral Aneurysms.Advances in experimental medicine and biology · 2024Review
- Hemodynamic study of blood flow in the aorta during the interventional robot treatment using fluid-structure interaction.Biomechanics and modeling in mechanobiology · 2023Article
- Haemodynamic Effects on the Development and Stability of Atherosclerotic Plaques in Arterial Blood Vessel.Interdisciplinary sciences, computational life sciences · 2023Article
- Modeling Dynamics of the Cardiovascular System Using Fluid-Structure Interaction Methods.Biology · 2023Review
- Onset and nature of flow-induced vibrations in cerebral aneurysms via fluid-structure interaction simulations.Biomechanics and modeling in mechanobiology · 2023Article
- A machine learning model for non-invasive detection of atherosclerotic coronary artery aneurysm.International journal of computer assisted radiology and surgery · 2022Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The biomechanical and hemodynamic effects of atherosclerosis on the initiation of intracranial aneurysms (IA) are not yet clearly discovered. Also, studies for the observation of hemodynamic variation due to atherosclerotic stenosis and its impact on arterial remodeling and aneurysm genesis remain a controversial field of vascular engineering. The majority of studies performed are relevant to computational fluid dynamic (CFD) simulations. CFD studies are limited in consideration of blood and arterial tissue interactions. In this work, the interaction of the blood and vessel tissue because of atherosclerotic occlusions is studied by developing a fluid and structure interaction (FSI) analysis for the first time. The FSI presents a semi-realistic simulation environment to observe how the blood and vessels' structural interactions can increase the accuracy of the biomechanical study results. In the first step, many different intracranial vessels are modeled for an investigation of the biomechanical and hemodynamic effects of atherosclerosis in arterial tissue remodeling. Three physiological conditions of an intact artery, the artery with intracranial atherosclerosis (ICAS), and an atherosclerotic aneurysm (ACA) are employed in the models with required assumptions. Finally, the obtained outputs are studied with comparative and statistical analyses according to the intact model in a normal physiological condition. The results show that existing occlusions in the cross-sectional area of the arteries play a determinative role in changing the hemodynamic behavior of the arterial segments. The undesirable variations in blood velocity and pressure throughout the vessels increase the risk of arterial tissue remodeling and aneurysm formation.
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