Evidence map›Paper›PMID 35697705›Full record

ArticleScientific reports2022

Using directional OCT to analyze photoreceptor visibility over AMD-related drusen.

Brennan Marsh-Armstrong, Kelly S Murrell, Denise Valente, Ravi S Jonnal

Abstract read
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In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brennan Marsh-ArmstrongUniversity of California, Davis Eye Center, Sacramento, USA. bmarshar@health.ucsd.edu.
Kelly S MurrellUniversity of California, Davis Eye Center, Sacramento, USA.
Denise ValenteUniversity of California, Davis Eye Center, Sacramento, USA.
Ravi S JonnalUniversity of California, Davis Eye Center, Sacramento, USA.

Funding

Structure and Function of the Chorioretinal Complex in Age-Related Macular DegeneR01EY024239 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WERNER, JOHN S · 2014 to 2018
$2.4M
Investigating fundamental properties and clinical applications of the optoretinogramR01EY033532 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Ravi S. Jonnal · 2022 to 2026
$2.0M
Properties of Photoreceptors and Muller Cells Investigated with AO-OCTR00EY026068 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JONNAL, RAVI S. · 2018 to 2020
$739k
NEI NIH HHS R00 EY026068NEI NIH HHS R01 EY024239NEI NIH HHS R01 EY033532NIH HHS R00-EY-026068NIH HHS R01-EY-024239
6 · The paper itself

Abstract

Investigators have reported reduced visibility of the cone photoreceptors overlying drusen using adaptive optics (AO) imaging techniques. Two hypotheses have been proposed to explain this phenomenon. First, the disease-related deformation of the photoreceptor outer segment (OS) may reduce its ability to act as a wave guide, thus decreasing the cell's familiar reflectance pattern. Second, drusen could disorient the photoreceptors away from the eye's pupil, reducing the amount of light reflected back out the pupil. In this work, we use directional OCT (dOCT) images of drusen in AMD patients to measure the respective contributions of these deforming and disorienting factors.

Indexed as

Retinal Cone Photoreceptor CellsTomography, Optical CoherenceHumansOptics and Photonics

Identifiers

PMID35697705
PMCPMC9192709

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.