Evidence map›Paper›PMID 35697583›Full record

ArticleUltrasound in medicine & biology2022

Material Properties, Dissolution and Time Evolution of PEGylated Lipid-Shelled Microbubbles: Effects of the Polyethylene Glycol Hydrophilic Chain Configurations.

Roozbeh H Azami, Mitra Aliabouzar, Jenna Osborn, Krishna N Kumar, Flemming Forsberg, John R Eisenbrey, Sanku Mallik, Kausik Sarkar

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Molecular-gated MRIMaterials today. Bio · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Harnessing Ultrasonic Technologies to TreatMolecules (Basel, Switzerland) · 2025
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Roozbeh H AzamiDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA.
Mitra AliabouzarDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA.
Jenna OsbornDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA.
Krishna N KumarDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA.
Flemming ForsbergDepartment of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
John R EisenbreyDepartment of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Sanku MallikDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota, USA.
Kausik SarkarDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA. Electronic address: sarkar@gwu.edu.
George Washington University · USThomas Jefferson University · USNorth Dakota State University · US

Funding

Targeting CLEC-2/podoplanin as a therapeutic strategy for pancreatic cancerP20GM109024 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI Sanku Mallik · 2016 to 2026
$20.5M
Echogenic Polymersomes for Triggered Contents ReleaseR01GM114080 · NIGMS · NORTH DAKOTA STATE UNIVERSITY · PI MALLIK, SANKU, SARKAR, KAUSIK · 2015 to 2023
$2.6M
Monodisperse Microbubbles for Noninvasive Pressure EstimationR01EB032333 · NIBIB · THOMAS JEFFERSON UNIVERSITY · PI EISENBREY, JOHN, SARKAR, KAUSIK · 2022 to 2025
$2.4M
NIBIB NIH HHS R01 EB032333NIGMS NIH HHS P20 GM109024NIGMS NIH HHS R01 GM114080
6 · The paper itself

Abstract

Polyethylene glycol (PEG) is often added to the lipid coating of a contrast microbubble to prevent coalescence and improve circulation. At high surface density, PEG chains are known to undergo a transition from a mushroom configuration to an extended brush configuration. We investigated the effects of PEG chain configuration on attenuation and dissolution of microbubbles by varying the molar ratio of the PEGylated lipid in the shell with three (0%, 2% and 5%) in the mushroom configuration and two (10% and 20%) in the brush configuration. We measured attenuation through the bubble suspensions and used it to obtain the characteristic rheological properties of their shells according to two interfacial rheological models. The interfacial elasticity was found to be significantly lower in the brush regime (∼0.6 N/m) than in the mushroom regime (∼1.3 N/m), but similar in value within each regime. The dissolution behavior of microbubbles under acoustic excitation inside an air-saturated medium was studied by measuring the time-dependent attenuation. Total attenuation recorded a transient increase because of growth resulting from air influx and an eventual decrease caused by dissolution. Microbubble shell composition with varying PEG concentrations had significant effects on dissolution dynamics.

Indexed as

MicrobubblesPolyethylene GlycolsContrast MediaLipidsSolubilityContrast MediaLipidsPolyethylene GlycolsAcoustic responseExponential elasticity modelInterfacial elasticityMicrobubble dissolutionPhospholipid-shelled microbubblesPolyethylene glycol configurationRheological propertiesTime-dependent attenuationUltrasound

Identifiers

PMID35697583
PMCPMC9357055
OpenAlexW4281671161

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.