ArticleACS biomaterials science & engineering2022
Loading with Biomolecules Modulates the Antioxidant Activity of Cerium-Doped Bioactive Glasses.
Article in ACS biomaterials science & engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Calcium, cobalt, strontium and cerium-based binary silicate bioactive nanoglasses: rational comparison in bioactive properties for optimizing tissue repair applications.Regenerative biomaterials · 2026Article
- Gelatin/Cerium-Doped Bioactive Glass Composites for Enhancing Cellular Functions of Human Mesenchymal Stem Cells (hBMSCs).Gels (Basel, Switzerland) · 2025Article
- Evaluation of the Properties of Bioactive Mesoporous Glasses Doped with Cerium and Loaded with Polyphenols.Materials (Basel, Switzerland) · 2025Article
- Stimulus-responsive smart bioactive glass composites for repair of complex tissue defects.Theranostics · 2025Review
- Bifunctional mesoporous glasses for bone tissue engineering: Biological effects of doping with cerium and polyphenols in 2D and 3D in vitro models.Biomaterials and biosystems · 2024Article
- Extraction, purification andHeliyon · 2024Article
- Advanced Biological Applications of Cerium Oxide Nanozymes in Disease Related to Oxidative Damage.ACS omega · 2024Review
- Ce-MBGs Loaded with Gentamicin: Characterization and In Vitro Evaluation.Journal of functional biomaterials · 2023Article
- Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies.Molecules (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to identify new bioactive glasses (BGs) with optimal antioxidant properties, we carried out an evaluation of a series of cerium-doped BGs [Ce-BGs─H, K, and mesoporous bioactive glasses (MBGs)] loaded with different biomolecules, namely, gallic acid, polyphenols (POLY), and anthocyanins. Quantification of loading at variable times highlighted POLY on MBGs as the system with the highest loading. The ability to dismutate hydrogen peroxide (catalase-like activity) of the BGs evaluated is strongly correlated with cerium doping, while it is marginally decreased compared to the parent BG upon loading with biomolecules. Conversely, unloaded Ce-BGs show only a marginal ability to dismutate the superoxide anion (SOD)-like activity, while upon loading with biomolecules, POLY in particular, the SOD-like activity is greatly enhanced for these materials. Doping with cerium and loading with biomolecules give complementary antioxidant properties to the BGs investigated; combined with the persistent bioactivity, this makes these materials prime candidates for upcoming studies on biological systems.
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