Evidence map›Paper›PMID 35696569›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Transcriptional and functional motifs defining renal function revealed by single-nucleus RNA sequencing.

Jun Xu, Yifang Liu, Hongjie Li, Alexander J Tarashansky, Colin H Kalicki, Ruei-Jiun Hung, Yanhui Hu, Aram Comjean, Sai Saroja Kolluru, Bo Wang and 5 more

Open access · hybridAbstract readDataset
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  7. The cryptonephridial/rectal complex: an evolutionary adaptation for water and ion conservation.Biological reviews of the Cambridge Philosophical Society · 2025
    Review
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  10. FlyPhoneDB2: A computational framework for analyzing cell-cell communication inComputational and structural biotechnology journal · 2025
    Article
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  14. Paraneoplastic renal dysfunction in fly cancer models driven by inflammatory activation of stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
  16. Cellular and molecular organization of the Drosophila foregut.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Jun XuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115.
Yifang LiuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115.
Hongjie LiDepartment of Biology, Stanford University, Stanford, CA 94305.
Alexander J TarashanskyDepartment of Bioengineering, Stanford University, Stanford, CA 94305.
Colin H KalickiDepartment of Bioengineering, Stanford University, Stanford, CA 94305.
Ruei-Jiun HungDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115.
Yanhui HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115.
Aram ComjeanDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115.
Sai Saroja KolluruDepartment of Bioengineering, Stanford University, Stanford, CA 94305.
Bo WangDepartment of Bioengineering, Stanford University, Stanford, CA 94305.ORCID 0000-0001-8880-1432
Stephen R QuakeDepartment of Bioengineering, Stanford University, Stanford, CA 94305.ORCID 0000-0002-1613-0809
Liqun LuoDepartment of Biology, Stanford University, Stanford, CA 94305.ORCID 0000-0001-5467-9264
Andrew P McMahonDepartment of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089.
Julian A T DowInstitute of Molecular, Cell & Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom.ORCID 0000-0002-9595-5146
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115.
Harvard University · USStanford University · USChan Zuckerberg Initiative (United States) · USUniversity of Glasgow · GBUniversity of Southern California · US

Funding

The USC (Re)Building the Kidney Coordinating CenterU01DK107350 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KESSELMAN, CARL, VALERIUS, MICHAEL TODD · 2015 to 2019
$9.0M
Assembly of the Central Olfactory Networks in DrosophilaR01DC005982 · NIDCD · STANFORD UNIVERSITY · PI LIQUN LUO · 2003 to 2026
$8.1M
GUDMAP2 - Production of Mouse Strains for Gene Anatomy of the Lower Urinary TractU01DK094526 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCMAHON, ANDREW P. · 2011 to 2015
$2.5M
Four-dimensional Modeling of Mouse and Human Nephrogenesis.U01DK110792 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCMAHON, ANDREW P. · 2016 to 2020
$1.9M
Characterizing age-related decline of neural circuits by single-cell profilingR00AG062746 · NIA · BAYLOR COLLEGE OF MEDICINE · PI LI, HONGJIE · 2021 to 2023
$996k
Howard Hughes Medical InstituteNIA NIH HHS R00 AG062746NIDCD NIH HHS R01 DC005982NIDDK NIH HHS U01 DK094526NIDDK NIH HHS U01 DK107350NIDDK NIH HHS U01 DK110792
6 · The paper itself

Abstract

Recent advances in single-cell sequencing provide a unique opportunity to gain novel insights into the diversity, lineage, and functions of cell types constituting a tissue/organ. Here, we performed a single-nucleus study of the adult

Indexed as

Drosophila melanogasterDrosophila ProteinsHepatocyte Nuclear Factor 4Malpighian TubulesNerve Tissue ProteinsTranscription FactorsAnimalsKidneyMiceRegenerationSequence Analysis, RNASingle-Cell AnalysisStem CellsDrosophila Proteinsfru protein, DrosophilaHepatocyte Nuclear Factor 4Nerve Tissue ProteinsTranscription Factorscross-specieskidney diseaseMalpighian tubulesnephrocytessnRNA-seq

Identifiers

PMID35696569
PMCPMC9231607
OpenAlexW4282585771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.