ArticleProceedings of the National Academy of Sciences of the United States of America2022
Indole-3-pyruvic acid regulates TAA1 activity, which plays a key role in coordinating the two steps of auxin biosynthesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 33 citations in OpenAlex.
- Tryptophan metabolism in tumor microenvironment and therapeutic implications.Journal of advanced research · 2026Review
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- The Influence of Wild Grapevine Endophytes on the Growth of the Model PlantLife (Basel, Switzerland) · 2026Article
- Unexpected Dual Function of Plant YUCCA Enzymes Links Chlorophyll Catabolism to Auxin Homeostasis.Angewandte Chemie (International ed. in English) · 2026Article
- Imperative roles of auxin signaling in reprogramming of drought tolerance in plants.Plant cell reports · 2026Review
- Auxin biosynthetic key geneFrontiers in plant science · 2026Article
- The HD-ZIP II Transcription Factors HAT3 and ATHB4 Fine-Tune Auxin and Cytokinin Pathways During Flower Development.Plants (Basel, Switzerland) · 2025Article
- Comparative Proteomic Analysis of Self-CompatiblePlant direct · 2025Article
- The auxin gatekeepers: Evolution and diversification of the YUCCA family.The Plant journal : for cell and molecular biology · 2025Article
- Mapping multi-substrate specificity of Arabidopsis aminotransferases.Nature plants · 2025Article
- From root to embryogenic transition: WOX5 reprograms plant somatic cells via auxin-mediated pathways.BMC plant biology · 2025Article
- Transcriptome analyses for revealing leaf abscission of Cyclocarya paliurus stem segments in vitro.BMC genomics · 2025Article
- The cytosolic aminotransferase VAS1 coordinates aromatic amino acid biosynthesis and metabolism.Science advances · 2024Article
- The Effect of External Treatment ofPlants (Basel, Switzerland) · 2024Article
- Role of transcriptional regulation in auxin-mediated response to abiotic stresses.Frontiers in genetics · 2024Review
- Non-canonical and developmental roles of the TCA cycle in plants.Current opinion in plant biology · 2023Review
- Precise Regulation of the TAA1/TAR-YUCCA Auxin Biosynthesis Pathway in Plants.International journal of molecular sciences · 2023Review
- New Wine in an Old Bottle: Utilizing Chemical Genetics to Dissect Apical Hook Development.Life (Basel, Switzerland) · 2022Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auxin biosynthesis involves two types of enzymes: the Trp aminotransferases (TAA/TARs) and the flavin monooxygenases (YUCCAs). This two-step pathway is highly conserved throughout the plant kingdom and is essential for almost all of the major developmental processes. Despite their importance, it is unclear how these enzymes are regulated and how their activities are coordinated. Here, we show that TAA1/TARs are regulated by their product indole-3-pyruvic acid (IPyA) (or its mimic KOK2099) via negative feedback regulation in
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