ArticleBiomacromolecules2022
Fast-Forming Dissolvable Redox-Responsive Hydrogels: Exploiting the Orthogonality of Thiol-Maleimide and Thiol-Disulfide Exchange Chemistry.
Article in Biomacromolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Architectural Tuning of Redox-Responsive Copolymer Hydrogels: Fast Gelation, Self-Healing, and Superior Mechanics via Block vs Random Networks.ACS polymers Au · 2026Article
- Thiol-Functionalized Succinoglycan via Cysteine Grafting: Enhanced Rheological Properties and Antioxidant Activity.Polymers · 2026Article
- On-Demand Chemically Degradable Hydrogels for Biological Applications.Chembiochem : a European journal of chemical biology · 2026Review
- Construction of artificial organellesChemical science · 2025Review
- Diverse reactivity of maleimides in polymer science and beyond.Polymer international · 2025Article
- Highly Thermally Conductive Liquid Crystalline Epoxy Resin Vitrimers with Reconfigurable, Shape-Memory, Photo-Thermal, and Closed-Loop Recycling Performance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Redox-Responsive Hydrogels Loaded with an Antibacterial Peptide as Controlled Drug Delivery for Healing Infectious Wounds.Advanced healthcare materials · 2024Article
- Metal-Free Click-Chemistry: A Powerful Tool for Fabricating Hydrogels for Biomedical Applications.Bioconjugate chemistry · 2024Review
- Disulfide-Cross-Linked Tetra-PEG Gels.Macromolecules · 2024Article
- Naked-Eye Thiol Analyte Detection via Self-Propagating, Amplified Reaction Cycle.Journal of the American Chemical Society · 2023Article
- Biomimetic strain-stiffening in fully synthetic dynamic-covalent hydrogel networks.Chemical science · 2023Article
- Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery.Pharmaceutics · 2023Review
- Fabrication Strategies Towards Hydrogels for Biomedical Application: Chemical and Mechanical Insights.Chemistry, an Asian journal · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fast-forming yet easily dissolvable hydrogels (HGs) have potential applications in wound healing, burn incidences, and delivery of therapeutic agents. Herein, a combination of a thiol-maleimide conjugation and thiol-disulfide exchange reaction is employed to fabricate fast-forming HGs which rapidly dissolve upon exposure to dithiothreitol (DTT), a nontoxic thiol-containing hydrophilic molecule. In particular, maleimide disulfide-terminated telechelic linear poly(ethylene glycol) (PEG) polymer and PEG-based tetrathiol macromonomers are employed as gel precursors, which upon mixing yield HGs within a minute. The selectivity of the thiol-maleimide conjugation in the presence of a disulfide linkage was established through
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