SynthesisPloS one2022
Risk factors for metabolic bone disease of prematurity: A meta-analysis.
Synthesis in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Prevention and management of metabolic bone disease of prematurity: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2026Pooled it
- Effects of mixed oil emulsion on short-term clinical outcomes in premature infants: A prospective, multicenter, randomized controlled trial.European journal of clinical nutrition · 2023Trial
- Metabolic bone disease of prematurity - what should we be measuring?Pediatric research · 2026Article
- Article
- Biomarkers of phosphate homeostasis and metabolic bone disease of prematurity: impact of early nutrition and regulation by vitamin D, iPTH, PTHrP, and FGF23.BMC pediatrics · 2026Article
- Biochemical metabolic bone disease in preterm infants: clinical determinants, markers and risk of fracture in a cohort study.BMC pediatrics · 2026Article
- Interventions for metabolic bone disease of prematurity: A systematic review and meta-analysis.Metabolism open · 2026Article
- Umbilical Cord Biomarkers of Nutritional and Metabolic Status in Neonates with Intrauterine Growth Restriction.Journal of clinical medicine · 2026Review
- Longitudinal course of bone health from infancy to mid-adulthood in preterm and term-born individuals.Scientific reports · 2025Article
- The Long-Term Impact of Preterm Birth on Metabolic Bone Profile and Bone Mineral Density in Childhood.Metabolites · 2025Article
- Incidence and Risk Factors for Metabolic Bone Disease of Prematurity in Indian Infants: A Prospective Observational Study.Indian pediatrics · 2025Observational
- Challenges in assessing bone health in early infancy: a narrative review of existing technologies.Frontiers in endocrinology · 2025Review
- Diagnostics of Metabolic Bone Disease in Extremely Preterm Infants-Clinical Applicability of Bone Turnover Biochemical Markers and Quantitative Ultrasound.Children (Basel, Switzerland) · 2024Article
- Incidence of metabolic bone disease in neonates under 32 gestational weeks at the Hospital Universitario de Santander in Colombia.Biomedica : revista del Instituto Nacional de Salud · 2024Article
- Analysis of clinical risk factors for metabolic bone disease of prematurity.Frontiers in pediatrics · 2024Article
- Calcium-phosphate metabolism - selected disorders in children.Pediatric endocrinology, diabetes, and metabolism · 2024Article
- Do birth outcomes mediate the association between drug use in pregnancy and neonatal metabolic bone disease? A prospective cohort study of 10,801 Chinese women.Frontiers in public health · 2024Article
- Prenatal and Neonatal Bone Health: Updated Review on Early Identification of Newborns at High Risk for Osteopenia.Nutrients · 2023Review
- Artificial Neural Network Modeling to Predict Neonatal Metabolic Bone Disease in the Prenatal and Postnatal Periods.JAMA network open · 2023Article
- A Quality Improvement Project to Decrease Fractures Secondary to Metabolic Bone Disease of Prematurity.Pediatric quality & safetyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the risk factors for metabolic bone disease of prematurity (MBDP), and to provide a reference for the prevention of MBDP.
methodsThe databases including China Biomedical Literature Service System, China National Knowledge Infrastructure, Wanfang Data, and Weipu Periodical Database, PubMed, Web of Science, Embase, Cochrane Library and other databases were searched for studies on the risk factors for MBDP published up to June 18, 2021. RevMan 5.3 and Stata 14.1 software were used to perform a Meta analysis.
resultsA total of 15 articles were included, including 13 case-control studies, 1 current investigation, and 1 retrospective cohort study. There were 1,435 cases in the case group and 2,057 cases in the control group, with a total sample size of 3,492 cases. Meta analysis showed that risk factors for MBDP include birth weight <1000g (OR = 6.62, 95%CI: 2.28-19.25), gestational age <32 weeks (OR = 2.73, 95%CI: 1.07-6.95), septicemia (OR = 2.53, 95%CI: 1.69-3.79), parenteral nutrition time (OR = 4.04, 95%CI: 1.72-9.49), cholestasis (OR = 3.50, 95%CI: 1.49-8.23), intrauterine growth retardation (OR = 6.89, 95%CI: 3.81-12.44), while the birth weight(OR = 0.44, 95%CI: 0.21-0.90) and gestational age (OR = 0.57, 95%CI: 0.44-0.73)are the protective factors of MBDP.
conclusionFactors like birth weight <1000g, gestational age <32 weeks, septicemia, parenteral nutrition time, cholestasis, and intrauterine growth retardation may increase the risk of metabolic bone disease of prematurity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.