ArticlePloS one2022
Ginseng of different ages is affected by the accumulation of heavy metals in ginseng soil.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
- Rapid analysis of mercury ion in real samples via ion-imprinted nanoparticle-based test strips.Analytical and bioanalytical chemistry · 2026Article
- Integrated multi-omics maps how processed black ginseng modulates gut homeostasis through rare ginsenosides.NPJ science of food · 2026Article
- Dynamic Coordination of Alternative Splicing and Subgenome Expression Bias Underlies Rusty Root Symptom Response inPlants (Basel, Switzerland) · 2025Article
- Preliminary exploration of the relationship between ginsenoside content and endogenous hormones of multi stem ginseng and soil properties based on correlation analysis.Frontiers in plant science · 2025Article
- Effects of soil properties and microbial community composition on ginsenosides accumulation in farmland ginseng.Frontiers in bioengineering and biotechnology · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Heavy-metal pollution has been established to affect ginseng quality. However, this effect is still unknown in ginseng of different ages, emphasizing the need to investigate the effects of heavy metals in soils on ginseng growth. Herein, we determined the content of heavy metals (Cu, Cd, Pb, Hg, and As) in ginseng of different ages (2 to 6-year-old) and the corresponding soil samples. Then, the total ginsenosides content of ginseng and rate-limiting enzyme (HMGR, SQE, CYP450) activity in the synthesis of ginsenosides were assessed. Results from 200 differently-aged Chinese ginseng showed that increased ginsenoside content in 3 to 5-year-old ginseng was paralleled by increased heavy metal element content in ginseng and its soil. The activity of rate-limiting enzymes increased in the first four years of ginseng growth and then exhibited a steady or downward trend. Further analysis suggested that heavy metal elements in soils could directly affect ginsenoside content. Moreover, we found that Cu significantly affected the rate-limiting enzyme CYP450 activity. Further principal component analysis and correlation analysis found that heavy metals could obviously inhibit ginseng growth during the 5th and 6th years. Heavy metal content in soils has huge prospects for predicting ginsenoside, Cu and As content in ginseng. This study provided support for ginseng cultivation, quality research and quality assessment.
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