Evidence map›Paper›PMID 35696348›Full record

ReviewJournal of natural products2022

Tolypocladamides A-G: Cytotoxic Peptaibols from

Sarath P D Senadeera, Dongdong Wang, Chang-Kwon Kim, Emily A Smith, David E Durrant, Patrick A Alexander, Karen L Wendt, Andrew G Stephen, Deborah K Morrison, Robert H Cichewicz and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in Journal of natural products, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Neuroprotective Indole Diterpenoids from the FungusPharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Sarath P D SenadeeraMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
Dongdong WangMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.ORCID 0000-0002-7824-2507
Chang-Kwon KimMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
Emily A SmithMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
David E DurrantLaboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
Patrick A AlexanderNational Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland 21701, United States.
Karen L WendtDepartment of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, and Natural Products Discovery Group and Institute for Natural Products Applications and Research Technologies, University of Oklahoma, Norman, Oklahoma 73019, United States.
Andrew G StephenNational Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland 21701, United States.
Deborah K MorrisonLaboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
Robert H CichewiczDepartment of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, and Natural Products Discovery Group and Institute for Natural Products Applications and Research Technologies, University of Oklahoma, Norman, Oklahoma 73019, United States.ORCID 0000-0003-0744-4117
Curtis J HenrichMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.
John A BeutlerMolecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States.ORCID 0000-0002-4646-1924
Leidos (United States) · USTarget (United States) · USNational Cancer Institute · USUniversity of Oklahoma · US

Funding

Regulation of Ras-Dependent Signal Transduction PathwaysZIABC010329 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MORRISON, DEBORAH · 2009 to 2025
$16.1M
Building Libraries with Chemical Diversity for ScreeningZIABC011469 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BEUTLER, JOHN · 2012 to 2025
$7.8M
Development of Natural Product Leads as Anticancer TherapeuticsZIABC011470 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BEUTLER, JOHN · 2012 to 2025
$7.8M
Accessing Natural Products from Silent Biosynthetic PathwaysR01GM092219 · NIGMS · UNIVERSITY OF OKLAHOMA · PI CICHEWICZ, ROBERT HENRY · 2010 to 2012
$1.1M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA BC010329Intramural NIH HHS ZIA BC011469Intramural NIH HHS ZIA BC011470NCI NIH HHS HHSN261200800001ENIGMS NIH HHS R01 GM092219
6 · The paper itself

Abstract

Seven new peptaibols named tolypocladamides A-G have been isolated from an extract of the fungus

Indexed as

Antineoplastic AgentsHypocrealesAmino AcidsCell Line, TumorPeptaibolsAmino AcidsAntineoplastic AgentsPeptaibols

Identifiers

PMID35696348
PMCPMC10616963
OpenAlexW4282578612

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.