Evidence map›Paper›PMID 35696340›Full record

ArticleThe Australian & New Zealand journal of obstetrics & gynaecology2023

Timing and temporal trends of influenza and pertussis vaccinations during pregnancy in three Australian jurisdictions: The Links2HealthierBubs population-based linked cohort study, 2012-2017.

Lisa Mchugh, Paul Van Buynder, Mohinder Sarna, Ross M Andrews, Hannah C Moore, Michael J Binks, Gavin Pereira, Christopher C Blyth, Karin Lust, Damien Foo and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Australian & New Zealand journal of obstetrics & gynaecology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Lisa MchughSchool of Public Health, University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0001-8580-9551
Paul Van BuynderSchool of Medicine and Dentistry, Griffith University, Southport, Queensland, Australia.ORCID 0000-0001-9113-938X
Mohinder SarnaCurtin School of Population Health, Curtin University, Perth, Western Australia, Australia.ORCID 0000-0002-2448-1588
Ross M AndrewsAustralian National University, Canberra, Australian Capital Territory, Australia.ORCID 0000-0001-6220-9019
Hannah C MooreCurtin School of Population Health, Curtin University, Perth, Western Australia, Australia.ORCID 0000-0001-6434-8290
Michael J BinksMenzies School of Health Research, Darwin, Northern Territory, Australia.ORCID 0000-0001-5455-690X
Gavin PereiraCurtin School of Population Health, Curtin University, Perth, Western Australia, Australia.ORCID 0000-0003-3740-8117
Christopher C BlythWesfarmers Centre for Vaccines & Infectious Diseases, Telethon Kids Institute, Perth, Western Australia, Australia.ORCID 0000-0003-2017-0683
Karin LustWomen's and Newborn Service, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.ORCID 0000-0002-6536-7191
Damien FooCurtin School of Population Health, Curtin University, Perth, Western Australia, Australia.ORCID 0000-0002-9396-6060
Annette K ReganCurtin School of Population Health, Curtin University, Perth, Western Australia, Australia.ORCID 0000-0002-3879-6193
The Kids Research Institute Australia · AUThe University of Queensland · AUAustralian National University · AUGriffith University · AUMenzies School of Health Research · AUNorwegian Institute of Public Health · NO

Funding

an NHMRC Career Development Fellowship GNT1111596an NHMRC Early Career Fellowship GNT1088733an NHMRC Early Career Fellowship GNT1138425Department of Health Western AustraliaNational Health and Medical Research Council GNT1141510NHMRC, Curtin University and the Wesfarmers Centre of Vaccines and Infectious Diseasethe NHMRC Council Centre of Research Excellence (CRE), the Australian Partnership for Preparedness Research on Infectious Disease Emergencies (APPRISE AppID 1116530)
6 · The paper itself

Abstract

backgroundAntenatal inactivated influenza (IIV) and pertussis-containing vaccines (dTpa) offer protection against severe respiratory infections for pregnant women and infants <6 months of age. Both vaccines are recommended in pregnancy; however, little is known about temporal or jurisdictional trends and predictors of uptake.

aimsTo identify gaps and predictors of IIV and/or dTpa vaccinations in Australian pregnancies from 2012 to 2017. MATERIALS AND

methodsWe conducted a probabilistically linked, multi-jurisdictional population-based cohort study, drawing from perinatal data collections and immunisation databases. We used a generalised linear mixed model with a random effect term to account for clustering of multiple pregnancies within mothers, to calculate vaccination uptake, and identify predictors of uptake by maternal demographic, pregnancy, and health characteristics.

resultsOf 591 868 unique pregnancies, IIV uptake was 15%, dTpa 27% and 12% received both vaccines. Pertussis vaccinations in First Nations pregnancies were 20% lower than non-Indigenous pregnancies; dTpa was strongly associated with IIV uptake (risk ratio (RR): 8.60, 95% CI 8.48-8.73). This trend was temporally and jurisdictionally consistent. First Nations women were more likely to have had IIV in pregnancy before the introduction of dTpa in the pregnancy program: (RR: 1.48, 95% CI 1.40-1.57), but less likely after dTpa implementation (RR: 0.78, 95% CI 0.76-0.80).

conclusionsInequity in vaccine uptake between First Nations and non-Indigenous pregnancies, and dismal rates of vaccination in pregnancy overall need urgent review, particularly before the next influenza pandemic or pertussis outbreak. If antenatal dTpa is driving IIV uptake, changes in antenatal healthcare practices are needed to ensure vaccines are offered equitably and optimally to protect against infection.

Indexed as

Influenza, HumanInfluenza VaccinesPregnancy Complications, InfectiousWhooping CoughAustraliaCohort StudiesFemaleHumansInfantPertussis VaccinePregnancyPregnancy, MultipleVaccinationInfluenza VaccinesPertussis Vaccineinfluenzapertussispregnancyuptakevaccination

Identifiers

PMID35696340
PMCPMC10952684
OpenAlexW4282568418

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.