Evidence map›Paper›PMID 35696134›Full record

ArticleTranslational vision science & technology2022

Characterization of Foveal Development in Treatment-Naïve Extremely Preterm Infants.

Ye He, Moritz Pettenkofer, Alison Chu, Srinivas R Sadda, Giulia Corradetti, Irena Tsui

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Article
  3. New Directions for Ophthalmic OCT - Handhelds, Surgery, and Robotics.Translational vision science & technology · 2025
    Review
  4. Article
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ye HeDepartment of Ophthalmology, Doheny Eye Institute, Stein Eye institute, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA.
Moritz PettenkoferDepartment of Ophthalmology, Doheny Eye Institute, Stein Eye institute, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA.
Alison ChuDepartment of Pediatrics, Division of Neonatology and Developmental Biology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA.
Srinivas R SaddaDepartment of Ophthalmology, Doheny Eye Institute, Stein Eye institute, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA.
Giulia CorradettiDepartment of Ophthalmology, Doheny Eye Institute, Stein Eye institute, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA.
Irena TsuiDepartment of Ophthalmology, Doheny Eye Institute, Stein Eye institute, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · USDoheny Eye Institute · USTianjin Medical University Eye Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To characterize and quantify foveal development in treatment-naïve extremely preterm infants using optical coherence tomography. Methods: In this cross-sectional study, eyes treated for retinopathy of prematurity before imaging were excluded. Inner retinal thickness and outer retina thickness at foveal center and foveal rim were assessed. Extremely preterm (EPT, <28 weeks gestational age) eyes were compared with infants more than 28 weeks of gestation using a multivariable dimension reduction analysis (principal component analysis) and a bilinear factor mode analysis (partial least square discriminant analysis) to determine group intervariability. Further analyses were performed to investigate the effects of gestation on foveal development. Results: Twenty-six infants born at gestational ages ranging from 22 to 39 weeks were imaged between 32 and 80 weeks postmenstrual age. A principal component analysis and partial least squares discriminant analysis revealed that the foveal inner retina thickness was the main difference between EPT infants and non-EPT infants. This difference was reflected by comparing their inner retinal thickness over time (32-80 weeks postmenstrual age), which revealed a sustained thicker foveal inner retina for EPT infants when compared with non-EPT infants. The foveal pit seemed to be shallower in EPT infants when compared with non-EPT infants. Conclusions: Twenty-eight weeks of gestation seems to be a critical timepoint for foveal development; EPT infants had altered foveal inner retinal development throughout early postnatal development, which led to a thicker foveal inner retina and a shallower foveal pit soon after birth. Translational Relevance: Measuring untreated foveal parameters informs about the effects of prematurity on the fovea and provides a baseline when comparing with post-treatment foveal development.

Indexed as

Infant, Extremely PrematureRetinopathy of PrematurityCross-Sectional StudiesFovea CentralisHumansInfantInfant, NewbornVisual Acuity

Identifiers

PMID35696134
PMCPMC9202331
OpenAlexW4282597082

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.