Evidence map›Paper›PMID 35695891›Full record

ArticleThe Journal of cell biology2022

A close shave: How SARS-CoV-2 induces the loss of cilia.

Barbara F Fonseca, Lisa A Chakrabarti

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. 1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Barbara F FonsecaControl of Chronic Viral Infections Group, Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR 3569, Paris, France.ORCID 0000-0001-6403-4099
Lisa A ChakrabartiControl of Chronic Viral Infections Group, Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR 3569, Paris, France.ORCID 0000-0002-1895-3630

Funding

Institut Pasteur
6 · The paper itself

Abstract

Wang et al. report in this issue (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2ZYG11B, leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-CoV-2 in the respiratory tree.

Indexed as

CiliaCOVID-19Ubiquitin-Protein LigasesCell Cycle ProteinsCullin ProteinsGenes, ViralHumansProteinsSARS-CoV-2Cell Cycle ProteinsCUL2 protein, humanCullin ProteinsProteinsUbiquitin-Protein LigasesZYG11A protein, human

Identifiers

PMID35695891
PMCPMC9198720

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.