ArticleeLife2022
RNA-binding proteins direct myogenic cell fate decisions.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- TDP-43 sustains satellite cells to maintain and regenerate skeletal muscle.Stem cell reports · 2026Article
- RNA Chemical Modifications in Mammalian Skeletal Muscle Development, Homeostasis, and Disease: Regulatory Mechanisms and Chemical Biology Perspectives.Molecules (Basel, Switzerland) · 2026Review
- Impaired Myogenic Differentiation Is a Shared Feature Across Genetic Myopathies.International journal of molecular sciences · 2026Review
- ReducedbioRxiv : the preprint server for biology · 2026Article
- The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells.FEBS open bio · 2026Article
- The Copper Chaperone ATOX1 Exhibits Differential Protein-Protein Interactions and Contributes to Skeletal Myoblast Differentiation.Molecular and cellular biology · 2026Article
- In-vitro human myogenesis model reveals novel mRNA alternative splicing isoforms.Scientific reports · 2025Article
- Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease.Nature communications · 2025Article
- Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle.FASEB bioAdvances · 2025Article
- Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle.bioRxiv : the preprint server for biology · 2025Article
- Article
- The Spatial-Temporal Alternative Splicing Profile Reveals the Functional Diversity of FXR1 Isoforms in Myogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Dysregulated FOXO1 activity drives skeletal muscle intrinsic dysfunction in amyotrophic lateral sclerosis.Acta neuropathologica · 2024Article
- Uncovering the dynamics and consequences of RNA isoform changes during neuronal differentiation.Molecular systems biology · 2024Article
- Research Progress on the Structural and Functional Roles of hnRNPs in Muscle Development.Biomolecules · 2023Review
- Muscle denervation promotes functional interactions between glial and mesenchymal cells through NGFR and NGF.iScience · 2023Article
- Regulation of Atp7a RNA contributes to differentiation-dependent Cu redistribution in skeletal muscle cells.Metallomics : integrated biometal science · 2023Article
- Article
- Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state.Molecular cell · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 6 institutions in 1 country.
Joshua R Wheeler *Department of Biochemistry, University of Colorado, Boulder, United States.ORCID https://orcid.org/0000-0002-7315-8269
Oscar N Whitney *Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0002-4858-2615
Thomas O VoglerMedical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, United States.ORCID https://orcid.org/0000-0002-4537-8248
Eric D NguyenMedical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, United States.
Bradley PawlikowskiDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, United States.
Evan LesterDepartment of Biochemistry, University of Colorado, Boulder, United States.
Alicia CutlerDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, United States.ORCID https://orcid.org/0000-0003-3365-0328
Tiffany ElstonDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, United States.
Nicole Dalla BettaDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, United States.
Kevin R ParkerCenter for Personal and Dynamic Regulomes, Stanford University, Palo Alto, United States.
Kathryn E YostCenter for Personal and Dynamic Regulomes, Stanford University, Palo Alto, United States.ORCID https://orcid.org/0000-0001-6807-950X
Hannes VogelDepartment of Pathology, Stanford University, Stanford, United States.
Thomas A RandoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, United States.ORCID https://orcid.org/0000-0001-5843-8564
Howard Y ChangCenter for Personal and Dynamic Regulomes, Stanford University, Palo Alto, United States.ORCID https://orcid.org/0000-0002-9459-4393
Aaron M JohnsonMolecular Biology Program and Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, United States.ORCID https://orcid.org/0000-0003-4553-1078
Roy ParkerHoward Hughes Medical Institute, University of Colorado, Boulder, United States.ORCID https://orcid.org/0000-0002-8412-4152
Bradley B OlwinDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, United States.ORCID https://orcid.org/0000-0001-6977-2509
University of Colorado Boulder · USHoward Hughes Medical Institute · USStanford University · USUniversity of Colorado Anschutz Medical Campus · USUniversity of California, Berkeley · USVA Palo Alto Health Care System · US
Funding
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0MMedical Scientist Training ProgramT32GM008497 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI WILSON, CARA C. · 1993 to 2022
$15.2MSpecial EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2014 to 2018
$15.2MCenter for Personal Dynamic RegulomesRM1HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2019 to 2023
$13.8MThe Role of Syndecans in Satellite Cell FunctionR01AR049446 · NIAMS · UNIVERSITY OF COLORADO AT BOULDER · PI Bradley B Olwin · 2005 to 2026
$7.2MReplicative Potential of Muscle Stem CellsR01AR070360 · NIAMS · UNIVERSITY OF COLORADO · PI Bradley B Olwin · 2017 to 2026
$4.2MStress Granules in Yeast and MammalsR01GM045443 · NIGMS · UNIVERSITY OF COLORADO · PI PARKER, ROY · 1991 to 2021
$3.3MmRNA Decapping in YeastR37GM045443 · NIGMS · UNIVERSITY OF COLORADO · PI PARKER, ROY · 2004 to 2013
$3.1MAging and Stem Cell ResilienceR01AG068667 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RANDO, THOMAS A. · 2021 to 2025
$2.8MMolecular Regulation of Stem Cell QuiescenceR01AR073248 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RANDO, THOMAS A. · 2018 to 2022
$2.6MMechanisms of heterochromatin targeting and epigenetic genome regulationR35GM144358 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Aaron M. Johnson · 2022 to 2026
$2.1MMechanisms of heterochromatin targeting and epigenetic genome regulationR35GM119575 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI JOHNSON, AARON M. · 2016 to 2020
$1.9MHoward Hughes Medical InstituteNCI NIH HHS P30 CA046934NCRR NIH HHS S10 RR026680NHGRI NIH HHS P50 HG007735NHGRI NIH HHS RM1 HG007735NIAMS NIH HHS F30 AR068881NIAMS NIH HHS R01 AR049446NIAMS NIH HHS R01 AR070360NIAMS NIH HHS R01 AR073248NIA NIH HHS R01 AG068667NIGMS NIH HHS R01 GM045443NIGMS NIH HHS R35 GM119575NIGMS NIH HHS R35 GM144358NIGMS NIH HHS R37 GM045443NIGMS NIH HHS T32 GM008497NINDS NIH HHS F30 NS093682
Abstract
RNA-binding proteins (RBPs), essential for skeletal muscle regeneration, cause muscle degeneration and neuromuscular disease when mutated. Why mutations in these ubiquitously expressed RBPs orchestrate complex tissue regeneration and direct cell fate decisions in skeletal muscle remains poorly understood. Single-cell RNA-sequencing of regenerating
Indexed as
Muscle DevelopmentMuscle Fibers, SkeletalAnimalsCell DifferentiationMiceMuscle, SkeletalRNA-Binding ProteinsRNA-Binding Proteinsmousepost-transcriptional regulationregenerationregenerative medicineRNA-binding proteinRNA splicingskeletal musclesplicing networkstem cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.