ArticleJournal of cardiovascular electrophysiology2022
Fever following Covid-19 vaccination in subjects with Brugada syndrome: Incidence and management.
Article in Journal of cardiovascular electrophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Temperature alters the inotropic and chronotropic effect of DNaunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Psychological profile of patients with Brugada syndrome and the impact of its diagnosis and management.NPJ cardiovascular health · 2025Review
- Can Hyperthermia Unveil Brugada Pattern?Journal of medical cases · 2024Article
- Cardiac Arrhythmias in Post-COVID Syndrome: Prevalence, Pathology, Diagnosis, and Treatment.Viruses · 2023Review
- Reply to fever, Covid-19 vaccination, and Brugada syndrome-Incidence and management: Correspondence.Journal of cardiovascular electrophysiology · 2022Article
- Fever, COVID-19 vaccination, and Brugada syndrome: Incidence and management-Correspondence.Journal of cardiovascular electrophysiology · 2022Article
- Fever following Covid-19 vaccination in subjects with Brugada syndrome: Incidence and management.Journal of cardiovascular electrophysiology · 2022Article
- Management of hemodynamically stable wide QRS complex tachycardia in patients with implantable cardioverter defibrillators.Frontiers in cardiovascular medicine · 2022Review
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFever is a potential side effect of the Covid-19 vaccination. Patients with Brugada syndrome (BrS) have an increased risk of life-threatening arrhythmias when experiencing fever. Prompt treatment with antipyretic drugs is suggested in these patients. AIM OF THE STUDY: To evaluate the incidence and management of fever within 48 h from Covid-19 vaccination among BrS patients.
methodsOne hundred sixty-three consecutive patients were enrolled in a prospective registry involving five European hospitals with a dedicated inherited disease ambulatory.
resultsThe mean age was 50 ± 14 years and 121 (75%) patients were male. Prevalence of Brugada electrocardiogram (ECG) pattern type-1, -2, and -3 was 32%, 44%, and 24%, respectively. Twenty-eight (17%) patients had an implantable cardioverter-defibrillator (ICD). Fever occurred in 32 (19%) BrS patients after 16 ± 10 h from vaccination, with a peak of body temperature of 37.9° ± 0.5°. Patients with fever were younger (39 ± 13 vs. 48 ± 13 years, p = .04). No additional differences in terms of sex and cardiovascular risk factors were found between patients with fever and not. Twenty-seven (84%) out of 32 patients experienced mild fever and five (16%) moderate fever. Pharmacological treatment with antipyretic drugs was required in 18 (56%) out of 32 patients and was associated with the resolution of symptoms. No patient required hospital admission and no arrhythmic episode was recorded in patients with ICD within 48 h after vaccination. No induced type 1 BrS ECG pattern and new ECG features were found among patients with moderate fever.
conclusionFever is a common side effect in BrS patients after the Covid-19 vaccination. Careful evaluation of body temperature and prompt treatment with antipyretic drugs may be needed.
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