ArticleEuropean heart journal2022
Outcomes of culture-negative vs. culture-positive infective endocarditis: the ESC-EORP EURO-ENDO registry.
Article in European heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 69 citations in OpenAlex.
- Residual cardiovascular risk in coronary artery disease: from pathophysiology to established and novel therapies.Nature reviews. Cardiology · 2026Review
- Impacts of blood culture-negative status on outcomes of infectious endocarditis patients with nonsurgical and surgical intervention.Medicine · 2026Article
- Clinical characteristics, treatment, and outcomes in CIED-related vs. left-sided infective endocarditis: a nationwide study from the NIDUS registry.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Comparative diagnostic performance of plasma microbial cell-free DNA sequencing versus amplicon-based blood next-generation sequencing in suspected bloodstream or endovascular infection: a single-center study.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Prolonged Culture Negativity in Infective Endocarditis Following Short-Term Antibiotic Exposure: A Case Report.Cureus · 2025Article
- Long-Term Prognosis and Surgical Outcomes of Culture-Negative Infective Endocarditis.Journal of the American Heart Association · 2025Article
- Recurrences of the infective endocarditis: clinical features and outcomes. Results from the Polish infective endocarditis registry (POL-ENDO).International journal of cardiology. Heart & vasculature · 2025Article
- Advances and Prospects in the Diagnosis and Treatment of Blood Culture-Negative Infective Endocarditis.Reviews in cardiovascular medicine · 2025Review
- Beyond Blood Cultures: The Promise of 16S rRNA Sequencing.JACC. Case reports · 2025Article
- Review
- [A case of brucella endocarditis in Tunisia].Medecine tropicale et sante internationale · 2025Article
- Transthoracic Echocardiography in Assessing Patients with Suspected Infective Endocarditis (TEASE): An Exploratory Study.Journal of clinical medicine · 2025Article
- 2-[18F]F-p-Aminobenzoic Acid Specifically Detects Infective Endocarditis in Positron Emission Tomography.The Journal of infectious diseases · 2025Article
- Identification of causative agents of infective endocarditis by metagenomic next-generation sequencing of resected valves.Frontiers in cellular and infection microbiology · 2025Article
- Article
- Clinical aspects and short-term prognosis in a cohort of patients with infective endocarditis, São Paulo, Brazil.Revista da Escola de Enfermagem da U S P · 2025Article
- Blood culture-negative endocarditis caused by Bartonella quintana in Iran.Scientific reports · 2024Article
- Infectious endocarditis complicated with intracranial infected aneurysm rupture and sinus of valsalva aneurysm rupture.BMC neurology · 2024Article
- Diagnostic Benefit of Molecular Imaging in Patients Undergoing Heart Valve Surgery for Infective Endocarditis.Microorganisms · 2024Article
- Infective Endocarditis in Belgium: Prospective Data in Adults from the ESC EORP European Endocarditis Registry.Journal of clinical medicine · 2024Article
Corrections and comments
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- Erratum issued
Authors and funding
25 authors at 18 institutions in 13 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimFatality of infective endocarditis (IE) is high worldwide, and its diagnosis remains a challenge. The objective of the present study was to compare the clinical characteristics and outcomes of patients with culture-positive (CPIE) vs. culture-negative IE (CNIE). METHODS AND
resultsThis was an ancillary analysis of the ESC-EORP EURO-ENDO registry. Overall, 3113 patients who were diagnosed with IE during the study period were included in the present study. Of these, 2590 (83.2%) had CPIE, whereas 523 (16.8%) had CNIE. As many as 1488 (48.1%) patients underwent cardiac surgery during the index hospitalization, 1259 (48.8%) with CPIE and 229 (44.5%) with CNIE. The CNIE was a predictor of 1-year mortality [hazard ratio (HR) 1.28, 95% confidence interval (CI) 1.04-1.56], whereas surgery was significantly associated with survival (HR 0.49, 95% CI 0.41-0.58). The 1-year mortality was significantly higher in CNIE than CPIE patients in the medical subgroup, but it was not significantly different in CNIE vs. CPIE patients who underwent surgery.
conclusionThe present analysis of the EURO-ENDO registry confirms a higher long-term mortality in patients with CNIE compared with patients with CPIE. This difference was present in patients receiving medical therapy alone and not in those who underwent surgery, with surgery being associated with reduced mortality. Additional efforts are required both to improve the aetiological diagnosis of IE and identify CNIE cases early before progressive disease potentially contraindicates surgery.
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