Evidence map›Paper›PMID 35695560›Full record

ReviewJournal of clinical microbiology2022

Antimicrobial Susceptibility Testing for Enterococci.

Ayesha Khan, William R Miller, Dierdre Axell-House, Jose M Munita, Cesar A Arias

Open access · greenAbstract readReview
In one paragraph

Review in Journal of clinical microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Evaluation of resistance mechanisms and susceptibility testing in Enterococcus spp.: implications of vancomycin-variable isolates and optrA-mediated resistance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  3. Vancomycin-Resistant, ThermotolerantFoods (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Article
  6. Cross-Sector Antimicrobial Resistance and Virulence inAntibiotics (Basel, Switzerland) · 2026
    Article
  7. Enterococcal bacteremia in children with malignancy or after hematopoietic stem cell transplantation: real-world multicenter data from a nationwide survey in Poland (2014-2021).European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  8. Article
  9. Article
  10. Non-susceptibility ofMicrobiology spectrum · 2026
    Article
  11. Article
  12. Article
  13. Genomic Characterization of Antibiotic-ResistantInfection and drug resistance · 2026
    Article
  14. Article
  15. Plasmid-linked virulence genes and high-level gentamicin resistance inJournal of conservative dentistry and endodontics · 2026
    Article
  16. Article
  17. From Isolation to Pilot-Scale Production:Foods (Basel, Switzerland) · 2025
    Article
  18. Antimicrobial Susceptibility ofMicroorganisms · 2025
    Article
  19. Review
  20. Evaluation of the Antimicrobial Potential ofJournal of tropical medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ayesha KhanGenomics & Resistant Microbes (GeRM) Group, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo, Santiago, Chile.ORCID 0000-0002-0489-0712
William R MillerDivision of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA.ORCID 0000-0002-1518-2973
Dierdre Axell-HouseDivision of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA.
Jose M MunitaGenomics & Resistant Microbes (GeRM) Group, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo, Santiago, Chile.
Cesar A AriasDivision of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA.ORCID 0000-0001-9054-9774
Houston Methodist · USUniversidad del Desarrollo · CL

Funding

Project 3: Functional Microbiome and Host Signatures in Transition from Commensal to pathogenP01AI152999 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HAAG, ANTHONY · 2020 to 2025
$12.0M
VENOUS: A translational study of enterococcal bacteremiaR01AI148342 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2020 to 2024
$3.9M
The LiaFSR system and antimicrobial peptide resistance in enterococciR01AI134637 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Cesar Augusto Arias · 2018 to 2026
$3.7M
POR Program on Genomic Prediction of Antimicrobial Resistance in VREK24AI121296 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2025
$1.5M
Role of YxdJK and DAK in the Enterococcal Envelope Stress ResponseK08AI135093 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILLER, WILLIAM R · 2018 to 2022
$929k
Enterococcus faecium virulence: A molecular and therapeutic approachR00AI072961 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2009 to 2010
$593k
NIAID NIH HHS K08 AI135093NIAID NIH HHS K24 AI121296NIAID NIH HHS P01 AI152999NIAID NIH HHS R00 AI072961NIAID NIH HHS R01 AI134637NIAID NIH HHS R01 AI148342
6 · The paper itself

Abstract

Enterococci are major, recalcitrant nosocomial pathogens with a wide repertoire of intrinsic and acquired resistance determinants and the potential of developing resistance to all clinically available antimicrobials. As such, multidrug-resistant enterococci are considered a serious public health threat. Due to limited treatment options and rapid emergence of resistance to all novel agents, the clinical microbiology laboratory plays a critical role in deploying accurate, reproducible, and feasible antimicrobial susceptibility testing methods to guide appropriate treatment of patients with deep-seated enterococcal infections. In this review, we provide an overview of the advantages and disadvantages of existing manual and automated methods that test susceptibility of Enterococcus faecium and Enterococcus faecalis to β-lactams, aminoglycosides, vancomycin, lipoglycopeptides, oxazolidinones, novel tetracycline-derivatives, and daptomycin. We also identify unique problems and gaps with the performance and clinical utility of antimicrobial susceptibility testing for enterococci, provide recommendations for clinical laboratories to circumvent select problems, and address potential future innovations that can bridge major gaps in susceptibility testing.

Indexed as

DaptomycinGram-Positive Bacterial InfectionsOxazolidinonesAminoglycosidesAnti-Bacterial Agentsbeta-LactamsEnterococcusHumansLipoglycopeptidesMicrobial Sensitivity TestsTetracyclineVancomycinAminoglycosidesAnti-Bacterial Agentsbeta-LactamsDaptomycinLipoglycopeptidesOxazolidinonesTetracyclineVancomycinantibiotic resistanceantimicrobial activityantimicrobial agentsclinical methodsdiagnosticsEnterococcusgram-positive bacteriahospital infectionsmultidrug resistancesusceptibility testing

Identifiers

PMID35695560
PMCPMC9491174
OpenAlexW4282835975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.