Evidence map›Paper›PMID 35695492›Full record

ArticlemSphere2022

Reconstitution of Mycobacterium marinum Nonhomologous DNA End Joining Pathway in

Wen-Wei Zhang, Douglas G Wright, Lynn Harrison, Greg Matlashewski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Wen-Wei ZhangDepartment of Microbiology and Immunology, McGill Universitygrid.14709.3b, Montreal, Quebec, Canada.ORCID 0000-0003-1996-876X
Douglas G WrightDepartment of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.
Lynn HarrisonDepartment of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.
Greg MatlashewskiDepartment of Microbiology and Immunology, McGill Universitygrid.14709.3b, Montreal, Quebec, Canada.ORCID 0000-0002-8971-5525
Louisiana State University Health Sciences Center Shreveport · USMcGill University · CA

Funding

CIHR
6 · The paper itself

Abstract

In mammalian cells, DNA double-strand breaks (DSBs) are mainly repaired by nonhomologous end joining (NHEJ) pathway. Ku (a heterodimer formed by Ku70 and Ku80 proteins) and DNA ligase IV are the core NHEJ factors. Ku could also be involved in other cellular processes, including telomere length regulation, DNA replication, transcription, and translation control.

Indexed as

LeishmaniaMycobacterium marinumAnimalsDNADNA-Binding ProteinsDNA End-Joining RepairDNA Ligase ATPHumansMammalsDNADNA-Binding ProteinsDNA Ligase ATPCRISPR-Cas9double-strand DNA breakDSB repairgene deletiongene targetingKuKu70Ku80Leishmania donovaniLigase DMycobacterium marinumNHEJnonhomologous end joiningsingle-strand annealingSSAtelomere maintenance

Identifiers

PMID35695492
PMCPMC9241504
OpenAlexW4282838644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.