ArticlemBio2022
iTDtest: an Easy-to-Handle and Visual Assay To Detect Tolerant and Persister Cells in an Antibiotic Combination Regimen.
Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed, 2 citations in OpenAlex.
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1 author at 1 institution in 1 country.
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Abstract
In a recent article, Balaban and colleagues developed the iTDtest allowing characterization of the type of interactions between different antibiotics at bactericidal concentrations (J.-F. Liu et al., mBio 13:e00004-22, 2022). This visual and semiquantitative assay is designed to determine how antibiotic cocktails affect tolerance and persistence, two phenomena of major importance for the eradication of difficult-to-treat pathogens. Importantly, Balaban and colleagues identified antibiotic combinations allowing for complete clearance of persister and tolerant cells. This commentary discusses the translation of this assay in clinical settings, where antibiotic combination therapies appear to be applied in specific contexts, such as in acute infections or in the case of multidrug or extensively drug-resistant pathogens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.