Evidence map›Paper›PMID 35695430›Full record

ArticlemSystems2022

Mind the Gap: Bridging the Divide from Sequencing Data to Empiric Phenotypes in the Human Gut Microbiota.

Ryan T Fansler, Wenhan Zhu

Open access · goldAbstract readComment
In one paragraph

Article in mSystems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ryan T FanslerDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-5432-8082
Wenhan ZhuDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0003-3771-0842
Vanderbilt University · US

Funding

Commensal resilience mechanisms in the inflamed intestineR35GM147470 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wenhan Zhu · 2022 to 2026
$2.2M
Commensal bacteria resilience mechanisms in the inflamed intestineR01DK134692 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wenhan Zhu · 2023 to 2026
$1.4M
Iron homeostasis in sustaining commensal resilience in the inflamed gutF31AI178950 · NIAID · VANDERBILT UNIVERSITY · PI Ryan T Fansler · 2024 to 2026
$105k
NIAID NIH HHS F31 AI178950NIDDK NIH HHS R01 DK134692NIGMS NIH HHS R35 GM147470
6 · The paper itself

Abstract

The gut microbiome exerts a powerful influence on human health and disease. Elucidating the underlying mechanisms of the microbiota's influence is hindered by the immense complexity of the gut microbial community and the glycans they forage. Despite a wealth of genomic and metagenomic sequencing information, there remains a lack of informative phenotypic measurements. Pudlo NA, Urs K, Crawford R, Pirani A, et al. (mSystems 7: e00947-21, 2022, https://doi.org/10.1128/msystems.00947-21) decode this complexity by introducing a scalable assay to measure specific carbohydrate utilization in the dominant microbiota phylum

Indexed as

Gastrointestinal MicrobiomeMicrobiotaBacteriaGenomicsHumansPolysaccharidesPolysaccharidesBacteroidetesglycan utilizationhuman gut microbiotaphenotypic assaypolysaccharide utilization

Identifiers

PMID35695430
PMCPMC9239041
OpenAlexW4282832426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.