ArticleKorean journal of radiology2022
Clinicoradiological Characteristics in the Differential Diagnosis of Follicular-Patterned Lesions of the Thyroid: A Multicenter Cohort Study.
Article in Korean journal of radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 10 citations in OpenAlex.
- Development of a predictive model using key ultrasound characteristics to distinguish follicular thyroid neoplasms from nodular goiter.Pakistan journal of medical sciences · 2026Article
- Preliminary machine-learning model with clinical, US, and CEUS features for the diagnosis of thyroid follicular-patterned lesions.BMC medical imaging · 2026Article
- Radiofrequency Ablation of Benign Thyroid Nodules: 10-Year Follow-Up Results From a Single Center.Korean journal of radiology · 2025Article
- Challenges in Preoperative Diagnosis for Thyroid Nodules Classified as Follicular Lesions of Undetermined Significance or Follicular Neoplasms.Journal of the Korean Society of Radiology · 2025Article
- Role of clinicopathologic and sonographic characteristics for the management of patients with cytological diagnosis of thyroid follicular neoplasm.Gland surgery · 2024Article
- Diagnostic value of an interpretable machine learning model based on clinical ultrasound features for follicular thyroid carcinoma.Quantitative imaging in medicine and surgery · 2024Article
- Development and validation of a predictive model for assessing the risk of follicular carcinoma in thyroid nodules identified as suspicious by intraoperative frozen section.Frontiers in endocrinology · 2024Article
- Improve follicular thyroid carcinoma diagnosis using computer aided diagnosis system on ultrasound images.Frontiers in oncology · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectivePreoperative differential diagnosis of follicular-patterned lesions is challenging. This multicenter cohort study investigated the clinicoradiological characteristics relevant to the differential diagnosis of such lesions. MATERIALS AND
methodsFrom June to September 2015, 4787 thyroid nodules (≥ 1.0 cm) with a final diagnosis of benign follicular nodule (BN, n = 4461), follicular adenoma (FA, n = 136), follicular carcinoma (FC, n = 62), or follicular variant of papillary thyroid carcinoma (FVPTC, n = 128) collected from 26 institutions were analyzed. The clinicoradiological characteristics of the lesions were compared among the different histological types using multivariable logistic regression analyses. The relative importance of the characteristics that distinguished histological types was determined using a random forest algorithm.
resultsCompared to BN (as the control group), the distinguishing features of follicular-patterned neoplasms (FA, FC, and FVPTC) were patient's age (odds ratio [OR], 0.969 per 1-year increase), lesion diameter (OR, 1.054 per 1-mm increase), presence of solid composition (OR, 2.255), presence of hypoechogenicity (OR, 2.181), and presence of halo (OR, 1.761) (all
conclusionAlthough follicular-patterned lesions have overlapping clinical and radiological features, the distinguishing features identified in our large clinical cohort may provide valuable information for preoperative distinction between them and decision-making regarding their management.
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