Evidence map›Paper›PMID 35695158›Full record

SynthesisActa ophthalmologica2022

What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review.

Els M Pameijer, Pauline Heus, Johanna A A Damen, René Spijker, Lotty Hooft, Peter J Ringens, Saskia M Imhof, Redmer van Leeuwen

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Acta ophthalmologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. B Vitamins and Ocular Health.Clinical ophthalmology (Auckland, N.Z.) · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Observational
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Observational
  20. Obesity, body fat distribution and eye diseases.Eating and weight disorders : EWD · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Els M Pameijer *Department of Ophthalmology, UMC Utrecht, Utrecht.ORCID https://orcid.org/0000-0001-9204-8893
Pauline Heus *Cochrane Netherlands and Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht University, The Netherlands.
Johanna A A DamenCochrane Netherlands and Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht University, The Netherlands.
René SpijkerCochrane Netherlands and Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht University, The Netherlands.
Lotty HooftCochrane Netherlands and Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht University, The Netherlands.
Peter J RingensDepartment of Ophthalmology, Maastricht University Medical Center, Maastricht, The Netherlands.
Saskia M ImhofDepartment of Ophthalmology, UMC Utrecht, Utrecht.
Redmer van LeeuwenDepartment of Ophthalmology, UMC Utrecht, Utrecht.ORCID https://orcid.org/0000-0002-9007-7276
Utrecht University · NLMaastricht University · NL

Funding

Zorginstituut Nederland
6 · The paper itself

Abstract

The aim of this paper is to summarize all available evidence from systematic reviews, randomized controlled trials (RCTs) and comparative nonrandomized studies (NRS) on the association between nutrition and antioxidant, vitamin, and mineral supplements and the development or progression of age-related macular degeneration (AMD). The Cochrane Database of Systematic Reviews, Cochrane register CENTRAL, MEDLINE and Embase were searched and studies published between January 2015 and May 2021 were included. The certainty of evidence was assessed according to the GRADE methodology. The main outcome measures were development of AMD, progression of AMD, and side effects. We included 7 systematic reviews, 7 RCTs, and 13 NRS. A high consumption of specific nutrients, i.e. β-carotene, lutein and zeaxanthin, copper, folate, magnesium, vitamin A, niacin, vitamin B6, vitamin C, docosahexaenoic acid, and eicosapentaenoic acid, was associated with a lower risk of progression of early to late AMD (high certainty of evidence). Use of antioxidant supplements and adherence to a Mediterranean diet, characterized by a high consumption of vegetables, whole grains, and nuts and a low consumption of red meat, were associated with a decreased risk of progression of early to late AMD (moderate certainty of evidence). A high consumption of alcohol was associated with a higher risk of developing AMD (moderate certainty of evidence). Supplementary vitamin C, vitamin E, or β-carotene were not associated with the development of AMD, and supplementary omega-3 fatty acids were not associated with progression to late AMD (high certainty of evidence). Research in the last 35 years included in our overview supports that a high intake of specific nutrients, the use of antioxidant supplements and adherence to a Mediterranean diet decrease the risk of progression of early to late AMD.

Indexed as

AntioxidantsMacular DegenerationAscorbic Acidbeta CaroteneDietary SupplementsHumansVitaminsAntioxidantsAscorbic Acidbeta CaroteneVitaminsage-related macular degenerationAMDCochranenutritionsupplementssystematic review

Identifiers

PMID35695158
PMCPMC9796889
OpenAlexW4282567508

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.