Evidence map›Paper›PMID 35695136›Full record

ArticleThe Analyst2022

Structural characterization and analysis of different epimers of neutral glycosphingolipid LcGg4 by ion mobility spectrometry-mass spectrometry.

Tianqi Gao, Aneirin A Lott, Fanran Huang, Rajendra Rohokale, Qingjiang Li, Hernando J Olivos, Sixue Chen, Zhongwu Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Analyst, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tianqi GaoDepartment of Chemistry, University of Florida, Gainesville, FL 32611, USA. zguo@chem.ufl.edu.
Aneirin A LottDepartment of Biology, Genetics Institute, University of Florida, Gainesville, FL 32611, USA.ORCID http://orcid.org/0000-0002-0424-5836
Fanran HuangDepartment of Chemistry, University of Florida, Gainesville, FL 32611, USA. zguo@chem.ufl.edu.
Rajendra RohokaleDepartment of Chemistry, University of Florida, Gainesville, FL 32611, USA. zguo@chem.ufl.edu.
Qingjiang LiDepartment of Chemistry, University of Florida, Gainesville, FL 32611, USA. zguo@chem.ufl.edu.
Hernando J OlivosWaters Corporation, 5 Technology Drive, Building B, Milford, MA 01757, USA.
Sixue ChenDepartment of Biology, Genetics Institute, University of Florida, Gainesville, FL 32611, USA.ORCID http://orcid.org/0000-0002-6690-7612
Zhongwu GuoDepartment of Chemistry, University of Florida, Gainesville, FL 32611, USA. zguo@chem.ufl.edu.ORCID http://orcid.org/0000-0001-5302-6456

Funding

Synthetic and Biological Studies of GPI Conjugates and GPI Anchorage to Cell MembranesR35GM131686 · NIGMS · UNIVERSITY OF FLORIDA · PI Zhongwu Guo · 2019 to 2026
$2.5M
Acquisition of a Q Exactive HF Hybrid Quadrupole-OrbitrapS10OD021758 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2017 to 2017
$600k
NIGMS NIH HHS R35 GM131686NIH HHS S10 OD021758
6 · The paper itself

Abstract

LcGg4, a neutral glycosphingolipid (GSL) and cancer antigen, its epimers GalNAc-LcGg4 and GlcNAc-LcGg4, and three lipid forms of GalNAc-LcGg4 were studied by mass spectrometry (MS). It was found that different forms of GalNAc-LcGg4 carrying homologous (d16:1/18:0) and (d18:1/18:0) lipids were easily separated and identified using liquid chromatography (LC)-MS. In addition, like gangliosides, homologous lipid forms of GalNAc-LcGg4 showed the same fragmentation pattern, except for a uniform shift of their glycolipid product ions by a certain

Indexed as

Ion Mobility SpectrometryNeutral GlycosphingolipidsChromatography, LiquidGangliosidesTandem Mass SpectrometryGangliosideslactogangliotetraosylceramideNeutral Glycosphingolipids

Identifiers

PMID35695136
PMCPMC9483844

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.