Trial reportTherapeutic advances in respiratory disease
Effect of physical training on cytokine expression in CD4+ T lymphocytes in subjects with stable COPD.
Trial report in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 12 citations in OpenAlex.
- Immune system benefits of pulmonary rehabilitation in chronic obstructive pulmonary disease.Experimental physiology · 2026Review
- Review
- Lifelong Exercise as a Modulator of CD4European journal of clinical investigation · 2026Review
- Low intensity vibration as a novel strategy to normalize age-related deficits in T cell proliferation, activation, and function.Scientific reports · 2026Article
- Short-term high-intensity resistance training: a feasibility study on pulmonary, immune and physical-functional fitness benefits for older adults with metabolic syndrome.European journal of applied physiology · 2026Article
- Evaluation of clinical impact of Interleukin 8 gene expression in patients with fibromyalgia.Advances in rheumatology (London, England) · 2025Article
- Exercise Prescription Training in Chronic Obstructive Pulmonary Disease: Benefits and Mechanisms.International journal of chronic obstructive pulmonary disease · 2025Review
- Exercise and nutrition benefit skeletal muscle: From influence factor and intervention strategy to molecular mechanism.Sports medicine and health science · 2024Review
- Lung transcriptomics reveals the underlying mechanism by which aerobic training enhances pulmonary function in chronic obstructive pulmonary disease.BMC pulmonary medicine · 2024Article
- Effects of pulmonary rehabilitation on systemic inflammation in chronic obstructive pulmonary disease: a meta-analysis.American journal of clinical and experimental immunology · 2024Review
- Manual therapy and exercise effects on inflammatory cytokines: a narrative overview.Frontiers in rehabilitation sciences · 2024Review
- The impact of supervised physical exercise on chemokines and cytokines in recovered COVID-19 patients.Frontiers in immunology · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough evidence suggests that physical exercise reduces systemic inflammation, at the plasma level, there are still contradictions in chronic obstructive pulmonary disease (COPD). In this sense, analysis of intracellular cytokines could clear off the effect of physical exercise on the inflammatory profile of these subjects.
aimThe aim was to evaluate the effect of physical training on cytokine expression in CD4+ T lymphocytes from subjects with COPD.
methodsThis is a randomized controlled trial. Subjects with stable COPD were grouped into two groups, exercise and control. In total, 23 subjects with stable COPD were evaluated, of which 15 underwent aerobic strength training [physical exercise group (PEG)] and 8 underwent breathing exercises [respiratory physiotherapy group (RPG)]. Intracellular cytokines [interleukin (IL)-8, IL-13, IL-17, IL-6, IL-2, IL-10, and tumor necrosis factor alpha (TNF-α)] from CD4+ T lymphocytes were analyzed from peripheral blood through flow cytometry, before and after 8 weeks of intervention.
resultsThe PEG and RPG groups had a mean age of 68 ± 5.96 and 72.25 ± 6.86 years and predicted forced expiratory volume in the first second (FEV
conclusionEight weeks of physical training, both peripheral and respiratory, were able to reduce concentrations of IL-8 and to increase IL-13, and TNF-α in CD4+ T lymphocytes in subjects with stable COPD. The findings reinforce the benefits of interventions in subjects with COPD, revealing data not previously investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.