Evidence map›Paper›PMID 35694687›Full record

ArticleRSC medicinal chemistry2022

Synthesis and evaluation of triazole congeners of nitro-benzothiazinones potentially active against drug resistant

Santosh Kumar Sahoo, Mohammad Naiyaz Ahmad, Grace Kaul, Srinivas Nanduri, Arunava Dasgupta, Sidharth Chopra, Venkata Madhavi Yaddanapudi

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Santosh Kumar SahooDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER) Balanagar Hyderabad 500037 Telangana India.ORCID https://orcid.org/0000-0002-0940-4584
Mohammad Naiyaz AhmadDivision of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute Sector 10, Janakipuram Extension, Sitapur Road Lucknow 226031 UP India.ORCID https://orcid.org/0000-0002-9300-6107
Grace KaulDivision of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute Sector 10, Janakipuram Extension, Sitapur Road Lucknow 226031 UP India.
Srinivas NanduriDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER) Balanagar Hyderabad 500037 Telangana India.ORCID https://orcid.org/0000-0002-6671-2022
Arunava DasguptaDivision of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute Sector 10, Janakipuram Extension, Sitapur Road Lucknow 226031 UP India.
Sidharth ChopraDivision of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute Sector 10, Janakipuram Extension, Sitapur Road Lucknow 226031 UP India.ORCID https://orcid.org/0000-0001-8823-6074
Venkata Madhavi YaddanapudiDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER) Balanagar Hyderabad 500037 Telangana India.ORCID https://orcid.org/0000-0002-9813-8694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With growing concerns regarding target residue mutation hovering over established anti-TB pharmacophores, it is imperative to have reserve chemotypes at our disposal to curb unrestrained spread of tuberculosis. In this context, we herein present the synthesis and bio-evaluation of a library of new nitrobenzothiazinone (BTZ) congeners comprising 2-mercapto/amino-benzothiazinone tethered 1,2,3-triazole hybrids as antitubercular agents. In preliminary screening, 10 out of 37 compounds displayed substantial

Identifiers

PMID35694687
PMCPMC9132192

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.